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Stimulation of breast cancer invasion and metastasis by synuclein gamma.

1999; National Institutes of Health; Volume: 59; Issue: 3 Linguagem: Inglês

Tongli Jia, Y. E. Liu, Jingwen Liu, Y. Eric Shi,

Alzheimer's disease research and treatments

We recently identified and cloned novel breast cancer-specific gene BCSG1 by direct differential cDNA sequencing. BCSG1 has a great sequence homology with the Alzheimer's disease related neural protein synuclein (SNC); thus, it was also named SNC-gamma. Overexpression of SNC-gamma in breast cancer cells leads to a significant increase in motility and invasiveness in vitro and a profound augmentation of metastasis in vivo. Our data suggest that this member of the neural protein SNCs might have important functions outside the central nervous system and may play a role in breast cancer progression.