Portal de Periódicos da CAPES

Studies with Hydroxyurea VII. Hydroxyurea and the Synthesis of Functional Proteins

1967; American Society for Microbiology; Volume: 94; Issue: 4 Linguagem: Inglês

10.1128/jb.94.4.1025-1033.1967

1098-5530

Herbert S. Rosenkranz, Elaine B. Winshell, Aiga Mednis, Howard S. Carr, Cornelia J. Ellner,

Chemical Reaction Mechanisms

Hydroxyurea affected neither the synthesis nor the degradation of bacterial messenger-ribonucleic acid. The proteins made by hydroxyurea-treated cells were structurally intact and fully functional. Since the expression of the lethal action of hydroxyurea requires active protein production, the data indicate that treated cells do not die as the result of the synthesis of abnormal proteins.