Activities of Brush Border Lactase, Acid β-Galactosidase, and Hetero-β-Galactosidase in the Jejunum of the Zambian African
1973; Elsevier BV; Volume: 64; Issue: 3 Linguagem: Inglês
10.1016/s0016-5085(73)80163-5
ISSN1528-0012
AutoresGordon Cook, N.‐G. Asp, Arne Dahlqvist,
Tópico(s)Biomedical Research and Pathophysiology
ResumoThe activities of brush border lactase, lysosomal acid β-galactosidase, and cytoplasmic hetero-β-galactosidase have been measured in jejunal biopsies from 26 Zambian African subjects. All of them had adult hypolactasia. A low activity of brush border lactase was demonstrated, and that amounted to 5 to 90% (mean 62) of the total lactase activity at pH 6.0. Acid β-galactosidase and hetero-β-galactosidase activities were not decreased. Oral lactose tolerance tests were abnormal in 25 of the subjects, and 21 had gastrointestinal symptoms. There was a significant correlation between brush border lactase activity and the maximum blood glucose rise after oral lactose (P
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