Carcinoembryonic antigen and alpha 1-fetoprotein in ulcerative colitis and regional enteritis.
1974; National Institutes of Health; Volume: 110; Issue: 7 Linguagem: Inglês
Autores
W. G. Thompson, Richard Gillies, H. Silver, J. Shuster, Samuel O. Freedman, Phil Gold,
Tópico(s)Pregnancy and Medication Impact
ResumoSera were collected from 108 patients with inflammatory bowel disease and assayed for carcinoembryonic antigen (CEA) and alpha(1)-fetoprotein (AFP). Seven (14%) of 51 patients with ulcerative colitis had a positive test for CEA and one of these had associated carcinoma of the colon. Ten (19%) of 52 patients with regional enteritis were also seropositive. The sera of 4 (9%) of 47 patients with ulcerative colitis and 2 (5%) of 41 patients with regional enteritis contained small amounts of AFP. Of two unclassified patients one had a positive CEA and the other a positive AFP. No serum was positive for both CEA and AFP. In addition, multiple samples were available for sequential analysis in eight CEA-positive patients but there was no apparent relationship between seropositivity and disease activity. Continued follow-up is now in progress to determine the significance of detectable fetal antigen levels in inflammatory bowel disease.
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