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Glucose and lipid metabolism and insulin sensitivity in type 1 diabetes: the effect of guar gum

1988; Elsevier BV; Volume: 48; Issue: 1 Linguagem: Inglês

10.1093/ajcn/48.1.98

1938-3207

Peter R. Ebeling, Hannele Yki‐Järvinen, A. Aro, Eero Helve, Mikko Sinisalo, VA Koivisto,

Food composition and properties

The effect of guar gum on glucose and lipid metabolism and on body insulin sensitivity was examined in nine type 1 diabetic patients treated with continuous subcutaneous insulin infusion. The study was done in a randomized, double-blind, crossover fashion with either guar gum or a placebo added to the usual diet four times per day for 4 wk each. Blood glucose levels after breakfast and lunch and daily insulin requirements were significantly lower during the guar-gum than the placebo diet. After a 4-wk guar-gum supplementation, blood glucose response to a test meal was significantly reduced by guar gum compared with the placebo. Hemoglobin A1 (HbA1) and insulin sensitivity remained unchanged. Serum total cholesterol fell by 21% (p less than 0.025). Thus, guar gum can reduce postprandial blood glucose, insulin requirements, and serum total cholesterol levels in type 1 diabetic patients.