The comparative efficacy of buspirone and diazepam in the treatment of anxiety
1979; American Psychiatric Association; Volume: 136; Issue: 9 Linguagem: Inglês
10.1176/ajp.136.9.1184
ISSN1535-7228
AutoresHarold L. Goldberg, Richard J. Finnerty,
Tópico(s)Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
ResumoBack to table of contents Previous article Next article No AccessThe comparative efficacy of buspirone and diazepam in the treatment of anxietyPublished Online:1 Apr 2006https://doi.org/10.1176/ajp.136.9.1184AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractIn this double-blind study, 56 adult psychoneurotic outpatients with a primary diagnosis of anxiety neurosis were randomly assigned to receive buspirone (N = 18), diazepam (N = 20), or placebo (N = 18) over a four- week period. A battery of tests administered weekly indicated that buspirone, a new agent not chemically related to any currently marketed drugs, was as effective an antianxiety agent as diazepam and produced no more and perhaps fewer side effects. Buspirone showed excellent antidepressant effects as well. If further studies confirm the authors' findings and determine that buspirone does not result in tolerance and addiction, it would be more advantageous than the benzodiazepines in the treatment of anxiety. Access content To read the fulltext, please use one of the options below to sign in or purchase access. Personal login Institutional Login Sign in via OpenAthens Purchase Save for later Item saved, go to cart PPV Articles - American Journal of Psychiatry $35.00 Add to cart PPV Articles - American Journal of Psychiatry Checkout Please login/register if you wish to pair your device and check access availability. Not a subscriber? Subscribe Now / Learn More PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development. Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.). FiguresReferencesCited byDetailsCited byDoes human serotonin-1A receptor polymorphism (rs6295) code for pain and associated symptoms in fibromyalgia syndrome?19 April 2021 | Reumatismo, Vol. 73, No. 1Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex29 June 2020 | Molecular Brain, Vol. 13, No. 1Translational Studies in the Complex Role of Neurotransmitter Systems in Anxiety and Anxiety Disorders31 January 2020Serotonin in panic and anxiety disorderseLife, Vol. 9Serotonergic system, cognition, and BPSD in Alzheimer's diseaseNeuroscience Letters, Vol. 704Dopaminergic Mechanisms Underlying Normal Variation in Trait Anxiety8 February 2019 | The Journal of Neuroscience, Vol. 39, No. 14Miscellaneous Serotonergic Agents2 January 2019Neuropsychopharmacology, Vol. 44, No. 4Cognitive, Affective, & Behavioral Neuroscience, Vol. 19, No. 1Journal of Child and Adolescent Psychopharmacology, Vol. 28, No. 1Novel 1-(2-pyrimidin-2-yl)piperazine derivatives as selective monoamine oxidase (MAO)-A inhibitors18 January 2017 | Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 32, No. 1, Vol. 39Neuroscience and Behavioral Physiology, Vol. 46, No. 2Quality of Life Research, Vol. 25, No. 4Behavioural Brain Research, Vol. 298Bioorganic & Medicinal Chemistry Letters, Vol. 26, No. 13Chinese Journal of Integrative Medicine, Vol. 21, No. 5Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, Vol. 115, No. 11Cochrane Database of Systematic ReviewsNeuropeptides, Vol. 48, No. 4Frontiers in Neural Circuits, Vol. 8Bioorganic & Medicinal Chemistry Letters, Vol. 23, No. 22International Journal of Neuropsychopharmacology, Vol. 16, No. 2Nature Reviews Drug Discovery, Vol. 12, No. 9Arylpiperazine‐Based 5‐HT 1A Receptor Partial Agonists and 5‐HT 2A Antagonists for the Treatment of Autism, Depression, Anxiety, Psychosis, and Schizophrenia22 March 2013Neurophysiology, Vol. 44, No. 1Neuropsychopharmacology, Vol. 37, No. 1Validated RP-HPLC Method for the Determination of Buspirone in Pharmaceutical FormulationsChromatography Research International, Vol. 2011Actions of Buspirone in a Putative Model of Anxiety in the Mouse12 April 2011 | Journal of Pharmacy and Pharmacology, Vol. 40, No. 7European Journal of Medicinal Chemistry, Vol. 46, No. 9Pharmacokinetics of Buspirone following Oral Administration to Rhesus Monkeys18 February 2010 | Journal of Pharmacy and Pharmacology, Vol. 51, No. 5, Vol. 21Cellular Signalling, Vol. 22, No. 10Neuroscience Letters, Vol. 473, No. 2Biological Psychiatry, Vol. 66, No. 7Bioorganic & Medicinal Chemistry Letters, Vol. 19, No. 4Fundamental & Clinical Pharmacology, Vol. 23, No. 3Buspirone induced acute and chronic changes of neural activation in the periaqueductal gray of ratsNeuroscience, Vol. 155, No. 1Structure‐Based In Silico Driven Optimization: Discovery of the Selective 5‐HT 1A Agonist PRX‐0002326 May 2008Journal of Heterocyclic Chemistry, Vol. 45, No. 4, Vol. 17Progress in Neurobiology, Vol. 86, No. 3Journal of Neurochemistry, Vol. 72, No. 5Lack of deleterious effects of buspirone on cognition in healthy male volunteers16 November 2016 | Journal of Psychopharmacology, Vol. 21, No. 2Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 50, No. 2Drug Discovery Today: Therapeutic Strategies, Vol. 3, No. 4Neuropharmacology, Vol. 50, No. 1Journal of Heterocyclic Chemistry, Vol. 42, No. 7Pediatric Clinics of North America, Vol. 52, No. 1Drug Metabolism and Disposition, Vol. 33, No. 2Limbic reductions of 5-HT 1A receptor binding in human temporal lobe epilepsy26 April 2004 | Neurology, Vol. 62, No. 8Biochemical Pharmacology, Vol. 67, No. 3Neuropsychopharmacology, Vol. 29, No. 3Brain Research, Vol. 928, No. 1-2Journal of Psychiatric Research, Vol. 36, No. 4Experimental and Clinical Psychopharmacology, Vol. 10, No. 4Behavioural Pharmacology, Vol. 13, No. 7Expert Review of Neurotherapeutics, Vol. 2, No. 5Pharmacokinetics and Tolerability of Buspirone during Oral Administration to Children and Adolescents with Anxiety Disorder and Normal Healthy Adults8 March 2013 | The Journal of Clinical Pharmacology, Vol. 41, No. 12Reducing Recidivism Among Mentally III Offenders: The Role of Psychotropic Medication in Correctional PsychiatryPsychiatric Annals, Vol. 31, No. 7, Vol. 38Pharmacology Biochemistry and Behavior, Vol. 70, No. 1Psychiatric Clinics of North America, Vol. 24, No. 1Behavioural Pharmacology, Vol. 12, No. 6The Multiplicity of Serotonin Receptors: Uselessly Diverse Molecules or an Embarrassment of Riches?29 June 2016 | The Neuroscientist, Vol. 6, No. 4, Vol. 129, Vol. 129European Journal of Pharmacology, Vol. 389, No. 2-3Pharmacology Biochemistry and Behavior, Vol. 66, No. 3European Neuropsychopharmacology, Vol. 10, No. 2Nuclear Medicine and Biology, Vol. 27, No. 5, Vol. 14New developments in the pharmacological treatment of anxiety28 October 1999 | Human Psychopharmacology: Clinical and Experimental, Vol. 14, No. S1Physiology & Behavior, Vol. 67, No. 5Journal of Clinical Psychopharmacology, Vol. 19, No. 1Enhancement of the Serotonin-Mediated Acetylcholine Release by Repeated Desmethylimipramine Treatment in the Hippocampus of Freely Moving RatsJapanese Journal of Pharmacology, Vol. 80, No. 4Pharmacology Biochemistry and Behavior, Vol. 60, No. 1Behavioural Brain Research, Vol. 96, No. 1-2Nuclear Medicine and Biology, Vol. 25, No. 8Journal of Clinical Psychopharmacology, Vol. 18, No. 4Brain Research, Vol. 761, No. 2, Vol. 114Pharmacology Biochemistry and Behavior, Vol. 54, No. 1Pharmacology Biochemistry and Behavior, Vol. 54, No. 1European Journal of Pharmacology, Vol. 318, No. 2-3Similar effects of buspirone and chlordiazepoxide on a fixed interval schedule with long-term, low-dose administration1 July 2016 | Journal of Psychopharmacology, Vol. 9, No. 4Biological Psychiatry, Vol. 38, No. 4Neuropharmacology, Vol. 34, No. 10Pharmacology & Therapeutics, Vol. 66, No. 2Pharmacology & Therapeutics, Vol. 66, No. 1Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 19, No. 2Alcohol, Vol. 12, No. 2Human Psychopharmacology: Clinical and Experimental, Vol. 9, No. 6Trends in Pharmacological Sciences, Vol. 15, No. 7Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 18, No. 1General Pharmacology: The Vascular System, Vol. 25, No. 4Journal of the American Academy of Child & Adolescent Psychiatry, Vol. 33, No. 7Expert Opinion on Investigational Drugs, Vol. 3, No. 55-HT 1A receptors and changes in extracellular 5-HT in the guinea-pig prefrontal cortex: involvement in aversive behaviour2 July 2016 | Journal of Psychopharmacology, Vol. 7, No. 4A review of clinical efficacy of 5-HT 1A agonists in anxiety and depression2 July 2016 | Journal of Psychopharmacology, Vol. 7, No. 3Human Psychopharmacology: Clinical and Experimental, Vol. 8, No. 2Human Psychopharmacology: Clinical and Experimental, Vol. 8, No. 5Psychopharmacology, Vol. 112, No. 1Biological Psychiatry, Vol. 33, No. 4Pharmacology Biochemistry and Behavior, Vol. 46, No. 3International Journal of Mental Health, Vol. 22, No. 2British Journal of Pharmacology, Vol. 108, No. 3British Journal of Pharmacology, Vol. 109, No. 4Acta Psychiatrica Scandinavica, Vol. 88, No. 1Current Opinion on Therapeutic Patents, Vol. 3, No. 1Stress Medicine, Vol. 8, No. 2Psychopharmacology, Vol. 107, No. 2-3Psychopharmacology, Vol. 106, No. 2Biological Psychiatry, Vol. 32, No. 1Brain Research Bulletin, Vol. 28, No. 4Current Therapeutic Research, Vol. 52, No. 3Current Therapeutic Research, Vol. 52, No. 3Neuroscience & Biobehavioral Reviews, Vol. 16, No. 1Physical Medicine and Rehabilitation Clinics of North America, Vol. 3, No. 2International Journal of Mental Health, Vol. 21, No. 3British Journal of Pharmacology, Vol. 107, No. 1Pharmacology & Toxicology, Vol. 70, No. 3Pharmacology & Toxicology, Vol. 71, No. 1Anxiogenic behavior in rats during acute and protracted ethanol withdrawal: Reversal by buspironeAlcohol, Vol. 8, No. 6Ethopharmacology of maternal aggression in mice: effects of diazepam and SM-3997European Journal of Pharmacology, Vol. 200, No. 1Effects of buspirone on fixed interval responding in rats2 July 2016 | Journal of Psychopharmacology, Vol. 5, No. 4Drug Development Research, Vol. 24, No. 1, Vol. 294Journal of Neural Transmission, Vol. 85, No. 3Psychopharmacology, Vol. 104, No. 3European Journal of Pharmacology, Vol. 193, No. 1European Journal of Pharmacology, Vol. 198, No. 2-3European Journal of Pharmacology, Vol. 204, No. 2Neuropharmacology, Vol. 30, No. 4Pharmacology Biochemistry and Behavior, Vol. 38, No. 3Pharmacology Biochemistry and Behavior, Vol. 40, No. 4Pharmacology Biochemistry and Behavior, Vol. 40, No. 4Pharmacology Biochemistry and Behavior, Vol. 40, No. 4Pharmacology Biochemistry and Behavior, Vol. 39, No. 2Pharmacology Biochemistry and Behavior, Vol. 38, No. 4Pharmacology Biochemistry and Behavior, Vol. 40, No. 1Pharmacology & Toxicology, Vol. 69, No. 3Medicinal Research Reviews, Vol. 10, No. 3Journal of Neural Transmission, Vol. 82, No. 3Psychopharmacology, Vol. 100, No. 4Psychopharmacology, Vol. 101, No. 3Psychopharmacology, Vol. 101, No. 3Psychopharmacology, Vol. 101, No. 4Psychopharmacology, Vol. 102, No. 1European Journal of Pharmacology, Vol. 176, No. 3European Journal of Pharmacology, Vol. 179, No. 3European Journal of Pharmacology, Vol. 178, No. 2European Journal of Pharmacology, Vol. 191, No. 3Pharmacology Biochemistry and Behavior, Vol. 37, No. 1Pharmacology Biochemistry and Behavior, Vol. 37, No. 2Pharmacology Biochemistry and Behavior, Vol. 35, No. 4Behavioral and Neural Biology, Vol. 54, No. 3Pharmacology & Therapeutics, Vol. 47, No. 2Journal of Neuroscience Methods, Vol. 34, No. 1-3Journal of Substance Abuse Treatment, Vol. 7, No. 3Journal of Anxiety Disorders, Vol. 4, No. 3American Review of Respiratory Disease, Vol. 141, No. 6Evaluation of Buspirone as an Antianxiety Agent: Buspirone and Diazepam versus Placebo *1 November 1989 | The Canadian Journal of Psychiatry, Vol. 34, No. 8Anticonflict effect of ipsapirone, buspirone and gepirone is not mediated by their common metabolite 1-(2-pyrimidinyl)piperazine2 July 2016 | Journal of Psychopharmacology, Vol. 3, No. 3Drug Development Research, Vol. 17, No. 3Human Psychopharmacology: Clinical and Experimental, Vol. 4, No. 1The Journal of Clinical Pharmacology, Vol. 29, No. 1Psychopharmacology, Vol. 99, No. 3Psychopharmacology, Vol. 99, No. 3Journal of Neural Transmission, Vol. 76, No. 2Neuropharmacology, Vol. 28, No. 5Pharmacology Biochemistry and Behavior, Vol. 32, No. 1Pharmacology Biochemistry and Behavior, Vol. 34, No. 2Pharmacology & Therapeutics, Vol. 44, No. 3The American Journal of the Medical Sciences, Vol. 297, No. 1Acta Psychiatrica Scandinavica, Vol. 79, No. 2American Review of Respiratory Disease, Vol. 139, No. 4Current Issues in Benzodiazepine Use for Anxiety DisordersPsychiatric Annals, Vol. 18, No. 3Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Vol. 8, No. 2Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 25, No. 4Psychopharmacology, Vol. 94, No. 1Brain Research, Vol. 461, No. 1European Journal of Pharmacology, Vol. 147, No. 3European Journal of Pharmacology, Vol. 155, No. 3Life Sciences, Vol. 42, No. 24Pharmacology Biochemistry and Behavior, Vol. 29, No. 4Pharmacology Biochemistry and Behavior, Vol. 31, No. 1Pharmacology Biochemistry and Behavior, Vol. 31, No. 2General Pharmacology: The Vascular System, Vol. 19, No. 3, Vol. 17The Lancet, Vol. 331, No. 8589British Journal of Pharmacology, Vol. 95, No. 1Journal of Asthma, Vol. 25, No. 5A Clinical Trial of Buspirone and Diazepam in the Treatment of Generalized Anxiety Disorder *1 June 1987 | The Canadian Journal of Psychiatry, Vol. 32, No. 5The Ideal AnxiolyticPsychiatric Annals, Vol. 17, No. 3Treatment of Anxiety with BuspironePsychiatric Annals, Vol. 17, No. 2Drug Development Research, Vol. 10, No. 2Drug Development Research, Vol. 10, No. 3Drug Development Research, Vol. 11, No. 2Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Vol. 7, No. 3Synapse, Vol. 1, No. 5Bulletin of Experimental Biology and Medicine, Vol. 103, No. 5The American Journal of Medicine, Vol. 82, No. 5The American Journal of Medicine, Vol. 82, No. 5The American Journal of Medicine, Vol. 82, No. 5The American Journal of Medicine, Vol. 82, No. 5European Journal of Pharmacology, Vol. 138, No. 1European Journal of Pharmacology, Vol. 134, No. 3Journal of Affective Disorders, Vol. 13, No. 2Trends in Pharmacological Sciences, Vol. 8, No. 10Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 11, No. 2-3Medical Hypotheses, Vol. 22, No. 3Alcohol, Vol. 4, No. 1Pharmacological Properties of SM-3997: A New Anxioselective Anxiolytic CandidateJapanese Journal of Pharmacology, Vol. 45, No. 4British Journal of Clinical Pharmacology, Vol. 23, No. 2The 5-HT1A agonists 8-OH-DPAT, buspirone and ipsapirone attenuate stress-induced anorexia in rats2 July 2016 | Journal of Psychopharmacology, Vol. 1, No. 1Archives Internationales de Physiologie et de Biochimie, Vol. 95, No. 3Archives Internationales de Physiologie et de Biochimie, Vol. 95, No. 4Failure of buspirone to manage benzodiazepine withdrawal1 April 2006 | American Journal of Psychiatry, Vol. 143, No. 12Naunyn-Schmiedeberg's Archives of Pharmacology, Vol. 334, No. 2The American Journal of Medicine, Vol. 80, No. 3The American Journal of Medicine, Vol. 80, No. 3The American Journal of Medicine, Vol. 80, No. 3The American Journal of Medicine, Vol. 80, No. 3The American Journal of Medicine, Vol. 80, No. 3The American Journal of Medicine, Vol. 80, No. 3European Journal of Pharmacology, Vol. 130, No. 1-2Neuropharmacology, Vol. 25, No. 11Pharmacology Biochemistry and Behavior, Vol. 24, No. 3Behavioural Brain Research, Vol. 21, No. 3Neuroscience Letters, Vol. 72, No. 1Journal of Pharmacy and Pharmacology, Vol. 38, No. 5Nordisk Psykiatrisk Tidsskrift, Vol. 40, No. sup13Buspirone: A New Type of Anxiolytic25 October 2017 | Drug Intelligence & Clinical Pharmacy, Vol. 19, No. 9Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Vol. 5, No. 5Naunyn-Schmiedeberg's Archives of Pharmacology, Vol. 329, No. 3Naunyn-Schmiedeberg's Archives of Pharmacology, Vol. 328, No. 4Journal of Neural Transmission, Vol. 64, No. 1Biochemical Pharmacology, Vol. 34, No. 3Biological Psychiatry, Vol. 20, No. 9Brain Research, Vol. 358, No. 1-2Pharmacology Biochemistry and Behavior, Vol. 23, No. 4Pharmacology Biochemistry and Behavior, Vol. 23, No. 4Neuroscience & Biobehavioral Reviews, Vol. 9, No. 1Xenobiotica, Vol. 15, No. 10Drug Development Research, Vol. 4, No. 1Drug Development Research, Vol. 4, No. 1Drug Development Research, Vol. 4, No. 1Drug Development Research, Vol. 4, No. 1Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Vol. 4, No. 6Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Vol. 4, No. 6Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Vol. 4, No. 6European Journal of Pharmacology, Vol. 106, No. 1Journal of Chromatography A, Vol. 283Nordisk Psykiatrisk Tidsskrift, Vol. 38, No. sup9Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 20, No. 10European Journal of Clinical Pharmacology, Vol. 24, No. 4Biochemical Pharmacology, Vol. 32, No. 6European Journal of Pharmacology, Vol. 88, No. 1Life Sciences, Vol. 33, No. 3Neuropharmacology, Vol. 22, No. 12Neuropharmacology, Vol. 22, No. 3Pharmacology Biochemistry and Behavior, Vol. 19, No. 1Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 7, No. 4-6Xenobiotica, Vol. 13, No. 3Psychopharmacology, Vol. 78, No. 1European Journal of Pharmacology, Vol. 86, No. 1Pharmacology Biochemistry and Behavior, Vol. 17Journal of Chromatography A, Vol. 252Journal of Pharmacy and Pharmacology, Vol. 34, No. 5PSYCHIATRY1 May 1980 | Medical Journal of Australia, Vol. 1, No. 9 Volume 136Issue 9 September 1979Pages 1184-1187 Metrics PDF download History Published online 1 April 2006 Published in print 1 September 1979
Referência(s)