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Incidence of Sperm-immobilizing Antibodies in Infertile Women with Past Chlamydia trachomatis Infection

2010; Wiley; Volume: 65; Issue: 2 Linguagem: Inglês

10.1111/j.1600-0897.2010.00883.x

1600-0897

Yuki Hirano, Hiroaki Shibahara, Junko Koriyama, Makoto Tokunaga, Kazuhiko Shimada, Mitsuaki Suzuki,

Genital Health and Disease

American Journal of Reproductive ImmunologyVolume 65, Issue 2 p. 127-132 ORIGINAL ARTICLE Incidence of Sperm-immobilizing Antibodies in Infertile Women with Past Chlamydia trachomatis Infection Yuki Hirano, Yuki Hirano Department Obstetrics and Gynecology, School of Medicine, Jichi Medical University and Center for Reproductive Medicine, Jichi Medical University Hospital, Tochigi, JapanSearch for more papers by this authorHiroaki Shibahara, Hiroaki Shibahara Department Obstetrics and Gynecology, School of Medicine, Jichi Medical University and Center for Reproductive Medicine, Jichi Medical University Hospital, Tochigi, JapanSearch for more papers by this authorJunko Koriyama, Junko Koriyama Department Obstetrics and Gynecology, School of Medicine, Jichi Medical University and Center for Reproductive Medicine, Jichi Medical University Hospital, Tochigi, JapanSearch for more papers by this authorMakoto Tokunaga, Makoto Tokunaga Department Obstetrics and Gynecology, School of Medicine, Jichi Medical University and Center for Reproductive Medicine, Jichi Medical University Hospital, Tochigi, JapanSearch for more papers by this authorKazuhiko Shimada, Kazuhiko Shimada Department Obstetrics and Gynecology, School of Medicine, Jichi Medical University and Center for Reproductive Medicine, Jichi Medical University Hospital, Tochigi, JapanSearch for more papers by this authorMitsuaki Suzuki, Mitsuaki Suzuki Department Obstetrics and Gynecology, School of Medicine, Jichi Medical University and Center for Reproductive Medicine, Jichi Medical University Hospital, Tochigi, JapanSearch for more papers by this author Yuki Hirano, Yuki Hirano Department Obstetrics and Gynecology, School of Medicine, Jichi Medical University and Center for Reproductive Medicine, Jichi Medical University Hospital, Tochigi, JapanSearch for more papers by this authorHiroaki Shibahara, Hiroaki Shibahara Department Obstetrics and Gynecology, School of Medicine, Jichi Medical University and Center for Reproductive Medicine, Jichi Medical University Hospital, Tochigi, JapanSearch for more papers by this authorJunko Koriyama, Junko Koriyama Department Obstetrics and Gynecology, School of Medicine, Jichi Medical University and Center for Reproductive Medicine, Jichi Medical University Hospital, Tochigi, JapanSearch for more papers by this authorMakoto Tokunaga, Makoto Tokunaga Department Obstetrics and Gynecology, School of Medicine, Jichi Medical University and Center for Reproductive Medicine, Jichi Medical University Hospital, Tochigi, JapanSearch for more papers by this authorKazuhiko Shimada, Kazuhiko Shimada Department Obstetrics and Gynecology, School of Medicine, Jichi Medical University and Center for Reproductive Medicine, Jichi Medical University Hospital, Tochigi, JapanSearch for more papers by this authorMitsuaki Suzuki, Mitsuaki Suzuki Department Obstetrics and Gynecology, School of Medicine, Jichi Medical University and Center for Reproductive Medicine, Jichi Medical University Hospital, Tochigi, JapanSearch for more papers by this author First published: 06 January 2011 https://doi.org/10.1111/j.1600-0897.2010.00883.xCitations: 11 Hiroaki Shibahara, Department Obstetrics and Gynecology, School of Medicine, Jichi Medical University and Center for Reproductive Medicine, Jichi Medical University Hospital, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.E-mail: [email protected] Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Citation Hirano Y, Shibahara H, Koriyama J, Tokunaga M, Shimada K, Suzuki M. Incidence of sperm-immobilizing antibodies in infertile women with past Chlamydia trachomatis infection. Am J Reprod Immunol 2011; 65: 127–132 Problem Among the risk factors for antisperm antibody production, inflammatory diseases of the genital tract are believed to play an important role. Chlamydia trachomatis infection is one of the most common sexually transmitted diseases. There are some reports suggesting that human sperm have antigens that cross-react immunologically with certain microbial antigens, such as C. trachomatis. However, this is still controversial. We performed a retrospective study to investigate the correlation between anti-chlamydial antibodies and sperm-immobilizing antibodies in infertile women. Method of study Between January 2007 and March 2009, the presence of sperm-immobilizing antibodies was examined by the sperm immobilization test using sera from 273 infertile women. Anti-chlamydial antibodies (IgG and IgA) were examined to prove past C. trachomatis infection by ELISA using the same sera from infertile women. Results The overall incidence of sperm-immobilizing antibodies was 2.9% (8/273) in infertile women. The incidences of sperm-immobilizing antibodies were 6.4% (5/78) in cases with past C. trachomatis infection and 1.5% (3/195) in cases without past C. trachomatis infection. There was a significant difference between the two groups (P = 0.031). Conclusion A significantly higher incidence of sperm-immobilizing antibodies was noted in infertile women with past C. trachomatis infection compared with that of those without past C. trachomatis infection. This is the first demonstration that C. trachomatis infection could play a role in the production of sperm-immobilizing antibodies in infertile women. Citing Literature Volume65, Issue2February 2011Pages 127-132 RelatedInformation