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Enteroglucagon and substance P-Like immunoreactivity in argentaffin and argyrophil rectal carcinoids

1977; Springer Science+Business Media; Volume: 25; Issue: 1 Linguagem: Inglês

10.1007/bf02889426

0340-6075

Erik Wilander, Guida Maria Portela‐Gomes, Lars Grimelius, G. Lundqvist, Valdemar Skoog,

Growth Hormone and Insulin-like Growth Factors

A specific immunofluorescence for enteroglucagon or substance P or for both hormones was demonstrated in nine out of 12 examined rectal carcinoids. One tumor was argentaffin, contained ultrastructurally pleomorphic granules of the entero-chromaffin cell type, and showed immunofluorescence for substance P. The rest were non-argentaffin but were argyrophil with the Grimelius technique and contained round granules. The argyrophil carcinoids were immunoreactive to one or both hormones in eight cases and not fluorescent in three cases. In two of the non-argentaffin carcinoids a small number of argyrophil cells was found with the method of Sevier-Munger.