Side Effects of Self-Administration of Intracavernous Papaverine and Phentolamine for the Treatment of Impotence
1989; Lippincott Williams & Wilkins; Volume: 141; Issue: 1 Linguagem: Inglês
10.1016/s0022-5347(17)40585-4
ISSN1527-3792
AutoresStephen B. Levine, Stanley E. Althof, Louisa A. Turner, Candace B. Risen, Donald R. Bodner, Elroy D. Kursh, Martin I. Resnick,
Tópico(s)Reproductive Health and Technologies
ResumoBeginning October 1985, 111 men agreed to enter a prospective study of the side effects of low dose papaverine/phentolamine therapy. A total of 46 men dropped out, 30 during the initial phase. The percentage of men with painless nodules almost consistently doubled from one followup examination to the next: 8 per cent at 1 month, 17 per cent at 3 months, 32 per cent at 6 months and 57 per cent at 12 months. The average injection frequency of those with nodules was 2 1/2 times higher than those without nodules. Of the men 41 per cent required an increased dose of medications during followup, and 40 per cent of 50 men had at least 1 abnormality of liver function, most of these involving mild to moderate elevations of alkaline phosphatase and lactic dehydrogenase. Priapism was not encountered during self-injection but it did occur twice in 329 physician-administered injections. Careful regular monitoring of patients should continue as some patients enter the second year of treatment.
Referência(s)