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Structural studies of cysteine proteases and their inhibitors.

2001; Polish Biochemical Society; Volume: 48; Issue: 1 Linguagem: Inglês

10.18388/abp.2001_5108

1734-154X

Zbigniew Grzonka, Elżbieta Jankowska, Franciszek Kasprzykowski, Regina Kasprzykowska, Leszek Łankiewicz, Wiesław Wiczk, Ewa Wieczerzak, Jerzy Ciarkowski, Piotr Drabik, Robert Janowski, Maciej Kozak, Mariusz Jaskólski, Anders Grubb,

Oral and gingival health research

Cysteine proteases (CPs) are responsible for many biochemical processes occurring in living organisms and they have been implicated in the development and progression of several diseases that involve abnormal protein turnover. The activity of CPs is regulated among others by their specific inhibitors: cystatins. The main aim of this review is to discuss the structure-activity relationships of cysteine proteases and cystatins, as well as of some synthetic inhibitors of cysteine proteases structurally based on the binding fragments of cystatins.