Omega-amidase pathway in the degradation of glutamine in Neurospora crassa
1985; American Society for Microbiology; Volume: 161; Issue: 2 Linguagem: Inglês
10.1128/jb.161.2.807-809.1985
ISSN1098-5530
AutoresJ Calderón, Enrique Morett, Jaime Font de Mora,
Tópico(s)Polyamine Metabolism and Applications
ResumoEvidence for the participation of the glutamine transaminase-omega-amidase pathway in the utilization of glutamine in Neurospora crassa was obtained. Its participation is indicated by the in vitro activities of glutamine transaminase and omega-amidase, the in vivo accumulation of alpha-ketoglutaramate when an inhibitor of transamidases is present, and the inhibition by aminooxyacetic acid and 6-diazo-5-oxo-L-norleucine of the ammonium excreted in the presence of glutamine by a mutant strain that lacks glutamate dehydrogenase and glutamate synthase.
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