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Resveratrol and anti-atherogenic effects

2015; Taylor & Francis; Volume: 66; Issue: 6 Linguagem: Inglês

10.3109/09637486.2015.1077796

1465-3478

Graziano Riccioni, Maria Alessandra Gammone, Guido Tettamanti, Sonia Bergante, Francesca Pluchinotta, Nicolantonio D’Orazio,

PARP inhibition in cancer therapy

The role of inflammation and oxidative stress in atherosclerosis development has been increasingly well recognized over the past decade. Inflammation has a significant role at all stages of atherosclerosis, including initiation, progression and plaque formation. Resveratrol is a naturally occurring polyphenolic compound found in grape products, berry fruits and red wine. Its ability to behave therapeutically as a component of red wine has attracted wide attention. Accumulating evidence suggests that it is a highly pleiotropic molecule that modulates numerous targets and molecular functions. Epidemiological studies indicate that the Mediterranean diet, rich in resveratrol, is associated with a reduced risk of atherosclerosis. Resveratrol is believed to decrease circulating low-density lipoprotein cholesterol levels, reduce cardiovascular disease risk; it reduces lipid peroxidation, platelet aggregation and oxidative stress. Resveratrol is considered a safe compound, since no significant toxic effects have been demonstrated after administration of a broad range of concentrations, and an effective anti-atherogenic agent.