Artigo Acesso aberto Revisado por pares

Helicobacter hepaticus sp. nov., a microaerophilic bacterium isolated from livers and intestinal mucosal scrapings from mice

1994; American Society for Microbiology; Volume: 32; Issue: 5 Linguagem: Inglês

10.1128/jcm.32.5.1238-1245.1994

ISSN

1098-660X

Autores

James G. Fox, Floyd E. Dewhirst, J. G. TULLY, Bruce J. Paster, Lili Yan, Nancy S. Taylor, Michael J. Collins, Peter L. Gorelick, Jerrold M. Ward,

Tópico(s)

Probiotics and Fermented Foods

Resumo

A bacterium with a spiral shape and bipolar, single, sheathed flagella was isolated from the livers of mice with active, chronic hepatitis. The bacteria also colonized the cecal and colonic mucosae of mice. The bacterium grew at 37 degrees C under microaerophilic and anaerobic conditions, rapidly hydrolyzed urea, was catalase and oxidase positive, reduced nitrate to nitrite, and was resistant to cephalothin metronidazole. On the basis of 16S rRNA gene sequence analysis, the organism was classified as a novel helicobacter, Helicobacter hepaticus. This new helicobacter, like two other murine Helicobacter species, H. muridarum and "H. rappini," is an efficient colonizer of the gastrointestinal tract, but in addition, it has the pathogenic potential to elicit persistent hepatitis in mice.

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