Iron-regulated outer membrane protein of Bacteroides fragilis involved in heme uptake
1990; American Society for Microbiology; Volume: 58; Issue: 12 Linguagem: Inglês
10.1128/iai.58.12.3954-3958.1990
ISSN1098-5522
AutoresBen R. Otto, M. Sparrius, A M Verweij-van Vught, D. M. MacLaren,
Tópico(s)Microbial Community Ecology and Physiology
ResumoUnder iron starvation, Bacteroides fragilis expresses various iron-regulated outer membrane proteins. In this study, a deferrated minimal medium was used in growth experiments, and the role of one of these iron-regulated outer membrane proteins (a 44-kDa protein) in an iron uptake mechanism which acquires iron from heme compounds was elucidated. When a specific 44-kDa protein antiserum was used in a medium with heme as the only iron source, growth inhibition was observed. These results demonstrate that the 44-kDa outer membrane protein plays an important role in the uptake of heme in B. fragilis.
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