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Duration of untreated psychosis and acute remission of negative symptoms in a S outh A merican first‐episode psychosis cohort

2015; Wiley; Volume: 11; Issue: 1 Linguagem: Inglês

10.1111/eip.12266

1751-7893

Alfonso González‐Valderrama, Carmen Paz Castañeda, Cristián Mena, Juan Undurraga, Pilar Mondaca, Matías Yañez, Paula Bedregal, Rubén Nachar,

Psychosomatic Disorders and Their Treatments

Abstract Aim To determine the association between duration of untreated psychosis ( DUP ) and symptoms remission in a hospitalized first‐episode psychosis cohort. Methods Inpatients with a first‐episode non‐affective psychosis were recruited. Subjects were divided into two groups of long and short DUP using a 3‐month cut‐off point, and this was related to remission at 10 weeks of treatment. Multivariate analyses were performed. Results Fifty‐five inpatients were included. There were no differences in remission rates of positive symptoms. Up to 76.5% of the patients with a short DUP (<3 months) achieved remission of negative symptoms versus 31.6% in the DUP ≥ 3 months group ( P = 0.003). After controlling for relevant factors, patients with a shorter DUP were still three times more likely to achieve negative symptoms remission ( HR : 3.04, 95% CI 1.2–7.5). Conclusions DUP is a prognostic factor that should be considered at an early stage to identify a ‘high risk’ subgroup of persistent negative symptoms.