hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma.
1990; Springer Nature; Volume: 9; Issue: 2 Linguagem: Inglês
10.1002/j.1460-2075.1990.tb08125.x
ISSN1460-2075
AutoresCatherine Tomasetto, M. C. Rio, Cécile Gautier, C Wolf, Mara Hareuveni, Pierre Chambon, Richard Lathe,
Tópico(s)Glycosylation and Glycoproteins Research
ResumoResearch Article1 February 1990free access hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma. C. Tomasetto C. Tomasetto LGME-CNRS and U184-INSERM, Strasbourg, France. Search for more papers by this author M.C. Rio M.C. Rio LGME-CNRS and U184-INSERM, Strasbourg, France. Search for more papers by this author C. Gautier C. Gautier LGME-CNRS and U184-INSERM, Strasbourg, France. Search for more papers by this author C. Wolf C. Wolf LGME-CNRS and U184-INSERM, Strasbourg, France. Search for more papers by this author M. Hareuveni M. Hareuveni LGME-CNRS and U184-INSERM, Strasbourg, France. Search for more papers by this author P. Chambon P. Chambon LGME-CNRS and U184-INSERM, Strasbourg, France. Search for more papers by this author R. Lathe R. Lathe LGME-CNRS and U184-INSERM, Strasbourg, France. Search for more papers by this author C. Tomasetto C. Tomasetto LGME-CNRS and U184-INSERM, Strasbourg, France. Search for more papers by this author M.C. Rio M.C. Rio LGME-CNRS and U184-INSERM, Strasbourg, France. Search for more papers by this author C. Gautier C. Gautier LGME-CNRS and U184-INSERM, Strasbourg, France. Search for more papers by this author C. Wolf C. Wolf LGME-CNRS and U184-INSERM, Strasbourg, France. Search for more papers by this author M. Hareuveni M. Hareuveni LGME-CNRS and U184-INSERM, Strasbourg, France. Search for more papers by this author P. Chambon P. Chambon LGME-CNRS and U184-INSERM, Strasbourg, France. Search for more papers by this author R. Lathe R. Lathe LGME-CNRS and U184-INSERM, Strasbourg, France. Search for more papers by this author Author Information C. Tomasetto1, M.C. Rio1, C. Gautier1, C. Wolf1, M. Hareuveni1, P. Chambon1 and R. Lathe1 1LGME-CNRS and U184-INSERM, Strasbourg, France. The EMBO Journal (1990)9:407-414https://doi.org/10.1002/j.1460-2075.1990.tb08125.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Approximately 50% of human breast tumors secrete a small cysteine-rich protein, pS2, of unknown function. pS2 protein was recently found to be homologous to a porcine protein with hormonogastric activity, pancreatic spasmolytic polypeptide (PSP), in which the 5-cysteine domain present in pS2 is tandemly duplicated. We have characterized cDNA species encoding PSP and its human and mouse counterparts, hSP and mSP. We show that hSP and pS2 are separately encoded in the genome, and that the two proteins are co-expressed in normal stomach epithelium. However, expression of hSP was not detected in breast tumors. Computer analysis revealed that the pattern of conserved cysteine residues in hSP and pS2, the P domain, is present at the N termini of two other mammalian proteins, intestinal sucrase-isomaltase and lysosomal alpha-glucosidase. Previous ArticleNext Article Volume 9Issue 21 February 1990In this issue RelatedDetailsLoading ...
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