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Stereopsis Results at 4.5 Years of Age in the Infant Aphakia Treatment Study

2014; Elsevier BV; Volume: 159; Issue: 1 Linguagem: Inglês

10.1016/j.ajo.2014.09.028

1879-1891

E. Eugenie Hartmann, Ann U. Stout, Michael Lynn, Kimberly G. Yen, Stacey J. Kruger, Scott R. Lambert, Scott R. Lambert, Lindreth DuBois, Michael Lynn, Betsy Bridgman, Marianne Celano, Julia Cleveland, George Cotsonis, Carolyn Drews‐Botsch, Nana Freret, Lu Lu, Seegar Swanson, Thandeka Tutu-Gxashe, E. Eugenie Hartmann, Anna Carrigan, Clara Edwards, C. Busettini, Samuel Hayley, Eleanor Lewis, Alicia Kindred, Joost Felius, Edward G. Buckley, David A. Plager, M. Edward Wilson, Carolyn Drews‐Botsch, Donald F. Everett, Margaret Bozic, Ann M. Holleschau, Buddy Russell, Michael Ward, Carol Bradham, Deborah K. VanderVeen, Theresa A. Mansfield, Kathryn B. Miller, Stephen P. Christiansen, Erick D. Bothun, Jason Jedlicka, Patricia Winters, J Lang, Elias I. Traboulsi, Susan Crowe, Heather Hasley Cimino, Faruk Örge, Megin Kwiatkowski, Beth Colon, Kimberly G. Yen, Maria Castanes, Alma Sanchez, Shirley York, Stacy Malone, Margaret Olfson, David T. Wheeler, Ann U. Stout, Paula K. Rauch, Kimberly Beaudet, Pam Berg, Amy K. Hutchinson, Rachel Robb, Marla J. Shainberg, Sharon F. Freedman, Lois Duncan, B.W. Phillips, John T. Petrowski, David Morrison, Sandy Owings, Ron Biernacki, Christine Franklin, Daniel E. Neely, Michele E. Whitaker, D. Bates, Dana Donaldson, Stacey J. Kruger, Charlotte Tibi, Susan Vega, David R. Weakley, David R. Stager, Clare Dias, Debra L. Sager, Todd Brantley, Robert J. Hardy, Eileen E. Birch, Ken Cheng, Richard W. Hertle, Craig Kollman, Marshalyn Yeargin‐Allsopp, Cyd McDowell, Allen D. Beck,

Mitochondrial Function and Pathology

Purpose To determine whether stereopsis of infants treated for monocular cataracts varies with the type of optical correction used. Design Randomized prospective clinical trial. Methods The Infant Aphakia Treatment Study randomized 114 patients with unilateral cataracts at age 1–7 months to either primary intraocular lens (IOL) or contact lens correction. At 4.5 years of age a masked examiner assessed stereopsis on these patients using 3 different tests: (1) Frisby; (2) Randot Preschool; and (3) Titmus Fly. Results Twenty-eight patients (25%) had a positive response to at least 1 of the stereopsis tests. There was no statistically significant difference in stereopsis between the 2 treatment groups: Frisby (contact lens, 6 [11%]; IOL, 7 [13%]; P = .99), Randot (contact lens, 3 [6%]; IOL, 1 [2%]; P = .62), or Titmus (contact lens, 8 [15%]; IOL, 13 [23%]; P = .34). The median age at surgery for patients with stereopsis was younger than for those without stereopsis (1.2 vs 2.4 months; P = .002). The median visual acuity for patients with stereopsis was better than for those without stereopsis (20/40 vs 20/252; P = .0003). Conclusion The type of optical correction did not influence stereopsis outcomes. However, 2 other factors did: age at surgery and visual acuity in the treated eye at age 4.5 years. Early surgery for unilateral congenital cataract and the presence of visual acuity better than or equal to 20/40 appear to be more important than the type of initial optical correction used for the development of stereopsis. To determine whether stereopsis of infants treated for monocular cataracts varies with the type of optical correction used. Randomized prospective clinical trial. The Infant Aphakia Treatment Study randomized 114 patients with unilateral cataracts at age 1–7 months to either primary intraocular lens (IOL) or contact lens correction. At 4.5 years of age a masked examiner assessed stereopsis on these patients using 3 different tests: (1) Frisby; (2) Randot Preschool; and (3) Titmus Fly. Twenty-eight patients (25%) had a positive response to at least 1 of the stereopsis tests. There was no statistically significant difference in stereopsis between the 2 treatment groups: Frisby (contact lens, 6 [11%]; IOL, 7 [13%]; P = .99), Randot (contact lens, 3 [6%]; IOL, 1 [2%]; P = .62), or Titmus (contact lens, 8 [15%]; IOL, 13 [23%]; P = .34). The median age at surgery for patients with stereopsis was younger than for those without stereopsis (1.2 vs 2.4 months; P = .002). The median visual acuity for patients with stereopsis was better than for those without stereopsis (20/40 vs 20/252; P = .0003). The type of optical correction did not influence stereopsis outcomes. However, 2 other factors did: age at surgery and visual acuity in the treated eye at age 4.5 years. Early surgery for unilateral congenital cataract and the presence of visual acuity better than or equal to 20/40 appear to be more important than the type of initial optical correction used for the development of stereopsis.