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Molecular Recognition by Induced Fit: How Fit is the Concept?

2001; American Physiological Society; Volume: 16; Issue: 4 Linguagem: Inglês

10.1152/physiologyonline.2001.16.4.171

1548-9213

Hans Rudolf Bosshard,

Computational Drug Discovery Methods

Induced fit explains why biomolecules can bind together even if they are not optimized for binding. However, induced fit can lead to a kinetic bottleneck and does not describe every interaction in the absence of prior complementarity. Preselection of a fitting conformer is an alternative to induced fit.