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The Impact of Prior Radiation Therapy on Artificial Urinary Sphincter Device Survival

2015; Lippincott Williams & Wilkins; Volume: 195; Issue: 4 Part 1 Linguagem: Inglês

10.1016/j.juro.2015.10.119

1527-3792

Marcelino Rivera, Brian J. Linder, Matthew Ziegelmann, Boyd R. Viers, Laureano J. Rangel, Daniel S. Elliott,

Prostate Cancer Diagnosis and Treatment

No AccessJournal of UrologyAdult Urology1 Apr 2016The Impact of Prior Radiation Therapy on Artificial Urinary Sphincter Device Survival Marcelino E. Rivera, Brian J. Linder, Matthew J. Ziegelmann, Boyd R. Viers, Laureano J. Rangel, and Daniel S. Elliott Marcelino E. RiveraMarcelino E. Rivera More articles by this author , Brian J. LinderBrian J. Linder More articles by this author , Matthew J. ZiegelmannMatthew J. Ziegelmann More articles by this author , Boyd R. ViersBoyd R. Viers More articles by this author , Laureano J. RangelLaureano J. Rangel More articles by this author , and Daniel S. ElliottDaniel S. Elliott More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.10.119AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The literature on artificial urinary sphincter device survival in individuals with a history of radiation therapy is conflicting. We assess device survival outcomes among individuals after prior radiation therapy exposure undergoing primary artificial urinary sphincter placement. Materials and Methods: An institutional review board approved database of all patients who underwent artificial urinary sphincter surgery from 1999 to 2011 was used to assess device survival in patients treated with radiotherapy compared to individuals without radiotherapy exposure. Hazard regression and competing risk analysis were used to determine the association between radiation therapy and device outcomes. Results: From 1999 to 2011 a total of 872 patients underwent artificial urinary sphincter surgery at our institution. Of these patients 489 underwent primary artificial urinary sphincter placement, with 181 of 489 (37%) having received radiation therapy. Patients with prior radiation therapy were older (median age 72.0 vs 70.1 years, p <0.01) and had a higher median body mass index (29.4 vs 28.6 kg/m2, p <0.03) than those without radiation exposure. Rates of diabetes mellitus and hypertension were similar between the 2 groups. There was no significant difference in overall device survival between individuals who received radiation therapy and those without radiation therapy exposure, with 1 and 5-year device survival rates of 92% vs 90% and 77% vs 74%, respectively (p=0.24). Conclusions: While individuals who underwent radiation therapy were significantly older and had a higher body mass index, device survival was not significantly different between the 2 groups when using a cuff size greater than 3.5 cm. These findings will assist the urologist with the preoperative counseling of men undergoing primary artificial urinary sphincter placement with a history of radiation therapy. 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Link, Google Scholar © 2016 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byHuang M, Huffman P, Dani H, Knijnik P, da Silva A, Burnett A, Mostwin J, Wright E and Cohen A (2022) Association between Previous Pelvic Radiation and All-Cause and Cause-Specific Failure of Replacement Artificial Urinary SphinctersJournal of Urology, VOL. 207, NO. 6, (1268-1275), Online publication date: 1-Jun-2022.Fuller T, Ballon-Landa E, Gallo K, Smith T, Ajay D, Westney O, Elliott S, Alsikafi N, Breyer B, Cohen A, Vanni A, Broghammer J, Erickson B, Myers J, Voelzke B, Zhao L and Buckley J (2020) Outcomes and Risk Factors of Revision and Replacement Artificial Urinary Sphincter Implantation in Radiated and Nonradiated CasesJournal of Urology, VOL. 204, NO. 1, (110-114), Online publication date: 1-Jul-2020.Ziegelmann M, Linder B, Avant R and Elliott D (2019) Bacterial Cultures at the Time of Artificial Urinary Sphincter Revision Surgery in Clinically Uninfected Devices: A Contemporary SeriesJournal of Urology, VOL. 201, NO. 6, (1152-1157), Online publication date: 1-Jun-2019.Kaufman M, Milam D, Johnsen N, Cleves M, Broghammer J, Brant W, Jones L, Brady J, Gross M and Henry G (2017) Prior Radiation Therapy Decreases Time to Idiopathic Erosion of Artificial Urinary Sphincter: A Multi-Institutional AnalysisJournal of Urology, VOL. 199, NO. 4, (1037-1041), Online publication date: 1-Apr-2018. Volume 195Issue 4 Part 1April 2016Page: 1033-1037 Advertisement Copyright & Permissions© 2016 by American Urological Association Education and Research, Inc.Keywordsradiotherapyurinary incontinencetreatment outcomeurinary sphincter, artificialMetricsAuthor Information Marcelino E. Rivera More articles by this author Brian J. Linder More articles by this author Matthew J. Ziegelmann More articles by this author Boyd R. Viers More articles by this author Laureano J. Rangel More articles by this author Daniel S. Elliott More articles by this author Expand All Advertisement PDF downloadLoading ...