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Anticancer activities of anthocyanin extract from genotyped Solanum tuberosum L. “Vitelotte”

2015; Elsevier BV; Volume: 19; Linguagem: Inglês

10.1016/j.jff.2015.09.063

2214-9414

Paola Bontempo, Luigi De Masi, Vincenzo Carafa, Daniela Rigano, Lucia Scisciola, Concetta Iside, Roberto Grassi, Anna Maria Molinari, Riccardo Aversano, Angela Nebbioso, Domenico Carputo, Lucia Altucci,

Plant Pathogens and Resistance

The action of anthocyanins contained in the Vitelotte potato (Solanum tuberosum L.) in both breast and haematological cancers were investigated. The biomedical activities of anthocyanin extract derived from the Vitelotte cultivar were determined. Molecular genotyping was performed to properly identify this outstanding genotype in comparison to other potato varieties and to promote the utilization of this genetic resource by plant breeders. Furthermore, cellular and molecular characterization of the action of anthocyanin extract in cancer cells revealed that modulation of cell cycle regulators occurs upon treatment. As well as inducing apoptotic players such as TRAIL in cancer systems, anthocyanin extract inhibited Akt-mTOR signalling thereby inducing maturation of acute myeloid leukaemia cells. These results are of interest in view of the impact on food consumption and as functional food components on potential cancer treatment and prevention.