Artigo Acesso aberto Produção Nacional

Intoxicação crônica por cobre em ovinos no norte do Paraná, Brasil: relato de caso

2008; UNIVERSIDADE ESTADUAL DE LONDRINA; Volume: 29; Issue: 1 Linguagem: Inglês

10.5433/1679-0359.2008v29n1p179

ISSN

1679-0359

Autores

Selwyn Arlington Headley, Antônio Carlos Faria dos Reis, Tizianne Larissa Duim Ribeiro Nakagawa, Ana Paula Frederico Rodrigues Loureiro Bracarense,

Tópico(s)

Drug Transport and Resistance Mechanisms

Resumo

Chronic copper poisoning (CCP) in sheep is a severe disease that occurs worldwide. This paper describes the pathological lesions of CCP that occurred in a flock of sheep from Northern Paraná, Southern Brazil. Seven, cross-breed Merino sheep, out of a flock of 14 were affected. Most of these animals demonstrated muscular tremors, nervous symptoms, difficult breathing, and died within 24-48 after the onset of clinical signs. Gross lesions were characterized by generalized icterus, hemoglobinuria, dark colored kidneys, and a softened spleen. Histological findings included tubular renal necrosis, centrilobular hepatic necrosis, and status spongiosis of the white matter of the brain; toxicological evaluation of the liver confirmed CCP.

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