
Intoxicação crônica por cobre em ovinos no norte do Paraná, Brasil: relato de caso
2008; UNIVERSIDADE ESTADUAL DE LONDRINA; Volume: 29; Issue: 1 Linguagem: Inglês
10.5433/1679-0359.2008v29n1p179
ISSN1679-0359
AutoresSelwyn Arlington Headley, Antônio Carlos Faria dos Reis, Tizianne Larissa Duim Ribeiro Nakagawa, Ana Paula Frederico Rodrigues Loureiro Bracarense,
Tópico(s)Drug Transport and Resistance Mechanisms
ResumoChronic copper poisoning (CCP) in sheep is a severe disease that occurs worldwide. This paper describes the pathological lesions of CCP that occurred in a flock of sheep from Northern Paraná, Southern Brazil. Seven, cross-breed Merino sheep, out of a flock of 14 were affected. Most of these animals demonstrated muscular tremors, nervous symptoms, difficult breathing, and died within 24-48 after the onset of clinical signs. Gross lesions were characterized by generalized icterus, hemoglobinuria, dark colored kidneys, and a softened spleen. Histological findings included tubular renal necrosis, centrilobular hepatic necrosis, and status spongiosis of the white matter of the brain; toxicological evaluation of the liver confirmed CCP.
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