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Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease

2005; Elsevier BV; Volume: 82; Issue: 6 Linguagem: Inglês

10.1093/ajcn/82.6.1320

1938-3207

David J. Stott, Graham MacIntosh, Gordon Lowe, Ann Rumley, Alex D. McMahon, Peter Langhorne, Robert C. Tait, D S O’Reilly, Edward G. Spilg, J Macdonald, Peter W. Macfarlane, Rudi GJ Westendorp,

Esophageal and GI Pathology

Background: Homocysteine is an independent risk factor for vascular disease and is associated with dementia in older people. Potential mechanisms include altered endothelial and hemostatic function. Objective: We aimed to determine the effects of folic acid plus vitamin B-12, riboflavin, and vitamin B-6 on homocysteine and cognitive function. Design: This was a factorial 2 × 2 × 2, randomized, placebo-controlled, double-blind study with 3 active treatments: folic acid (2.5 mg) plus vitamin B-12 (500 μg), vitamin B-6 (25 mg), and riboflavin (25 mg). We studied 185 patients aged ≥65 y with ischemic vascular disease. Outcome measures included plasma homocysteine, fibrinogen, and von Willebrand factor at 3 mo and cognitive change (determined with the use of the Letter Digit Coding Test and on the basis of the Telephone Interview of Cognitive Status) after 1 y. Results: The mean (±SD) baseline plasma homocysteine concentration was 16.5 ± 6.4 μmol/L. This value was 5.0 (95% CI: 3.8, 6.2) μmol/L lower in patients given folic acid plus vitamin B-12 than in patients not given folic acid plus vitamin B-12 but did not change significantly with vitamin B-6 or riboflavin treatment. Homocysteine lowering with folic acid plus vitamin B-12 had no significant effect, relative to the 2 other treatments, on fibrinogen, von Willebrand factor, or cognitive performance as measured by the Letter Digit Coding Test (mean change: −1; 95% CI: −2.3, 1.4) and the Telephone Interview of Cognitive Status (−0.7; 95% CI: −1.7, 0.4). Conclusion: Oral folic acid plus vitamin B-12 decreased homocysteine concentrations in elderly patients with vascular disease but was not associated with statistically significant beneficial effects on cognitive function over the short or medium term.