Protection of Germinal Epithelium with Luteinizing Hormone-Releasing Hormone Analogue
1985; Lippincott Williams & Wilkins; Volume: 134; Issue: 1 Linguagem: Inglês
10.1016/s0022-5347(17)47054-6
ISSN1527-3792
AutoresUnyime O. Nseyo, Robert P. Huben, Sol S. Klioze, J. Edson Pontes,
Tópico(s)Testicular diseases and treatments
ResumoA dog model for chemotherapy and radiation-induced testicular damage was created to study the protective potential of superactive analogue of luteinizing hormone-releasing hormone, buserelin. Buserelin appeared to offer protection of the canine germinal epithelium against cyclophosphamide, cisplatinum and radiation. Clinical trials with buserelin in patients of reproductive age undergoing treatment for cancer should be encouraged.
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