Some Biochemical Aspects Of The Relationship Between The Tumor And The Host
1972; Elsevier BV; Linguagem: Inglês
10.1016/s0065-230x(08)60377-2
ISSN2162-5557
Autores Tópico(s)Metabolism, Diabetes, and Cancer
ResumoThis chapter focuses on the tumor growing in its host; discusses the conditions that affect the metabolism of tumors in the host, the extent to which they allow the cancer cells to realize their potential capacity for respiration and glycolysis, and whether these processes in turn are able to implement in vivo their physiological function of energy transduction. A tendency to disturb the body homeostasis in one link—carbohydrate metabolism—may result in the derangement of the protein and lipid metabolism, owing to a forced gluconeogenesis as well, thus, requiring the endocrine systems, counterbalancing the effect of the tumor, to function under a constant strain and become prone to exhaustion. A high need of the tumor for glucose under in vivo conditions seems to be enhanced by (1) the extensive, uneconomical anaerobic glycolysis operating in the tumor because of local hypoxia and (2) the fact that the tumor is devoid of the enzymes of gluconeogenesis—that is, it is unable to produce glucose itself. The mechanism underlying the capacity of malignant tumors to grow destructively, infiltrating adjacent normal tissues, remains obscure. The most popular view relating to the problem appears to be that proteolytic enzymes or toxic substances liberated by tumors into the medium specifically destroy normal cells.
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