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The pharmacology and clinical pharmacokinetics of apomorphine SL

2001; Wiley; Volume: 88; Issue: s3 Linguagem: Inglês

10.1046/j.1464-4096.2001.00124.x

1464-410X

Antonio Argiolas, Hans Hedlund,

Epilepsy research and treatment

BJU InternationalVolume 88, Issue s3 p. 18-21 The pharmacology and clinical pharmacokinetics of apomorphine SL A. Argiolas, A. Argiolas Department of Neuroscience, University of Cagliari, Cittadella Universitaria, Monserrato, Italy andSearch for more papers by this authorH. Hedlund, H. Hedlund Department of Urology,The National Hospital, Oslo, NorwaySearch for more papers by this author A. Argiolas, A. Argiolas Department of Neuroscience, University of Cagliari, Cittadella Universitaria, Monserrato, Italy andSearch for more papers by this authorH. Hedlund, H. Hedlund Department of Urology,The National Hospital, Oslo, NorwaySearch for more papers by this author First published: 20 December 2001 https://doi.org/10.1046/j.1464-4096.2001.00124.xCitations: 36 A. Argiolas, Department of Neuroscience, University of Cagliari, Cittadella Universitaria, SS554, Km 4500, 09042 Monserrato (CA), Italy. e-mail: [email protected] Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Mathiessen A & Wright CRA. Researches into the chemical constitution of the opium bases. Part I. On the action of hydrochloric acid on morphine. Proc Roy Soc Ser B 1869; 17: 18– 21 2 Cotzias GC, Van Woert MH, Schiffer LM. Aromatic amino acids and modification of parkinsonism. N Engl J Med 1967; 276: 374– 9 3 Benassi-Bennelli A, Ferrari F, Pellegrini-Quarantotti B. Penile erection induced by apomorphine and N-n-propylnorapomorphine in rats. Arch Int Pharmacodyn Ther 1979; 242: 241– 7 4 Lal S. Apomorphine in the evaluation of dopaminergic function in man. Prog Neuropsychopharmacol Biol Psychiatry 1988; 12: 117– 64 5 Argiolas A & Melis MR. Neuromodulation of penile erection: an overview of the role of neurotransmitters and neuropeptides. Prog Neurobiol 1995; 47: 235– 55 6 Melis MR, Argiolas A, Gessa GL. Apomorphine-induced penile erection and yawning: site of action in brain. Brain Res 1987; 415: 98– 104 7 Chen KK, Chan SH, Chang LS. Dopaminergic neurotransmission at the paraventricular nucleus of hypothalamus in central regulation of penile erection in the rat. J Urol 1999; 162: 237– 42 8 Giuliano F & Rampin O. Central neural regulation of penile erection. Neurosci Biobehav Rev 2000; 24: 517– 33 9 Danjou P, Alexandre L, Warot D, Lacomblez L, Puech AJ. Assessment of erectogenic properties of apomorphine and yohimbine in man. Br J Clin Pharmacol 1988; 26: 733– 9 10 Lal S, Laryea E, Thavundayil JX et al. Apomorphine-induced penile tumescence in impotent patients – preliminary findings. Prog Neuropsychopharmacol Biol Psychiatry 1987; 11: 235– 42 11 Segraves RT, Bari M, Segraves K, Spirnak P. Effect of apomorphine on penile tumescence in men with psychogenic impotence. J Urol 1991; 145: 1174– 5 12 Neumeyer JL, Lal S, Baldessarini RJ. Historical highlights of the chemistry, pharmacology, and early clinical uses of apomorphine. Apomorphine and other dopaminomimetics. In GL Gessa, GU Corsini eds, Basic Pharmacology. New York: Raven Press, 1981; 1– 17 13 The Department of Health. British Pharmacopoeia. London: The Stationery Office, 2001: : 141 14 Vallone D, Picetti R, Borrelli E. Structure and function of dopamine receptors. Neurosci Biobehav Rev 2000; 24: 125– 32 15 CPMP Assessment Report for Ixense®. European Agency for the Evaluation of Medicinal Products, CPMP/217/01, London: 25 January, 2001 16 Ixense®, 2 mg and 3 mg, EU Summary of Product Characteristics, May 2001 17 Fagan TC, Buttler S, Marbury T, Taylor A, Edmonds A and the Uprima Study Group. Cardiovascular safety of sublingual apomorphine in patients on stable doses of oral antihypertensive agents and nitrates. Am J Cardiol 2001; in press Citing Literature Volume88, Issues3October 2001Pages 18-21 ReferencesRelatedInformation