Dissociation of influenza virus hemagglutinin and neuraminidase eliminates their intravirionic antigenic competition
1993; American Society for Microbiology; Volume: 67; Issue: 10 Linguagem: Inglês
10.1128/jvi.67.10.5721-5723.1993
ISSN1098-5514
AutoresBert E. Johansson, Edwin D. Kilbourne,
Tópico(s)Immune Cell Function and Interaction
ResumoWhen presented together on the intact influenza virus particle, the external hemagglutinin (HA) and neuraminidase (NA) antigens are competitive, with HA dominant over NA in both T- and B-cell priming (B. E. Johansson, T. M. Moran, and E. D. Kilbourne, Proc. Natl. Acad. Sci. USA 84:6869-6873, 1987). Dissociation and purification of HA and NA from virus and their injection separately or in combination into BALB/c mice eliminates their antigenic competition as measured by antibody response, confirming that it is their structural association that leads to what we have termed intravirionic antigenic competition. We discuss this phenomenon with respect to previously described intermolecular antigenic competition and with regard to its probable mechanism. Our findings are relevant to contemporary interest in viral vaccine vectors and multicomponent vaccines.
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