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Comparative biotransformation of aflatoxin B 1 in swine, domestic fowls, and humans

2015; Taylor & Francis; Volume: 34; Issue: 3 Linguagem: Inglês

10.3109/15569543.2015.1091979

1556-9551

Mayra Carraro Di Gregorio, Keliani Bordin, Pollyana Cristina Maggio de Castro Souto, Carlos Humberto Corassin, Carlos Augusto Fernandes de Oliveira,

Insect and Pesticide Research

Aflatoxin B1 (AFB1) is primarily biotransformed in the liver by cytochrome P450 (CYP) enzymes, which can yield either the genotoxic metabolite AFB1-8,9 epoxide that causes liver carcinogenicity or less toxic compounds. The biotransformation of AFB1 is better understood in humans, including gene expression of CYPs involved in the detoxification process. Studies on farm animals have demonstrated genes homologous to human CYPs that play similar roles in AFB1 biotransformation. This review compares the activities of the most important CYPs related to the biotransformation of AFB1 in humans, swine and domestic fowls (chickens, quail, turkeys and ducks), as well the main detoxification mechanisms in these species.