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Antibiotic therapy affects functional behaviour in cystic fibrosis blood mononuclear cells

2015; European Respiratory Society; Volume: 46; Issue: 2 Linguagem: Inglês

10.1183/09031936.00230214

1399-3003

Lorenzo Guerra, Maria Favia, Stefano Castellani, Giovanna Barbuti, P. Montemurro, Anna Diana, Teresa Santostasi, Angela Polizzi, Maria Addolorata Mariggiò, Stephan J. Reshkin, Antonio Manca, Valeria Casavola, Massimo Conese,

Inhalation and Respiratory Drug Delivery

Cystic fibrosis (CF) is the most common life-shortening genetic disorder in the Caucasian population and is due to mutations at the CF transmembrane conductance regulator ( CFTR ) gene leading to dysfunction of the protein, which normally acts as a chloride channel. This basic defect is associated with a progressive and lethal lung disease [1]. Opportunistic respiratory infections are common in CF patients' lungs, making antibiotics an important part of the regular care. Antibiotic therapy indirectly restores adequate levels of functional F508delCFTR in CF lymphomonocytes