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Photodamage to human skin by suberythemal exposure to solar ultraviolet radiation can be attenuated by sunscreens: a review

2010; Oxford University Press; Volume: 163; Issue: 5 Linguagem: Inglês

10.1111/j.1365-2133.2010.10018.x

1365-2133

Sophie Seité, Anny Fourtanier, D. Moyal, Antony R. Young,

Animal testing and alternatives

British Journal of DermatologyVolume 163, Issue 5 p. 903-914 Photodamage to human skin by suberythemal exposure to solar ultraviolet radiation can be attenuated by sunscreens: a review S. Seité, S. Seité La Roche-Posay Pharmaceutical Laboratories, 110 Avenue Henri Barbusse, 92602 Asnières Cedex, FranceSearch for more papers by this authorA. Fourtanier, A. Fourtanier L’Oréal Recherche, Clichy, FranceSearch for more papers by this authorD. Moyal, D. Moyal L’Oréal Recherche, Clichy, FranceSearch for more papers by this authorA.R. Young, A.R. Young St John’s Institute of Dermatology, King’s College London, London SE1 9RT, U.K.Search for more papers by this author S. Seité, S. Seité La Roche-Posay Pharmaceutical Laboratories, 110 Avenue Henri Barbusse, 92602 Asnières Cedex, FranceSearch for more papers by this authorA. Fourtanier, A. Fourtanier L’Oréal Recherche, Clichy, FranceSearch for more papers by this authorD. Moyal, D. Moyal L’Oréal Recherche, Clichy, FranceSearch for more papers by this authorA.R. Young, A.R. Young St John’s Institute of Dermatology, King’s College London, London SE1 9RT, U.K.Search for more papers by this author First published: 06 September 2010 https://doi.org/10.1111/j.1365-2133.2010.10018.xCitations: 93 Sophie Seité.E-mail: sseite@dca.loreal.com Conflicts of interestAll authors, except A.R.Y., are employees of L’Oréal. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Summary The effects of acute or repeated suberythemal solar ultraviolet radiation (UVR) exposure on human skin have been insufficiently investigated. Such exposure almost certainly has important long-term consequences that include skin ageing and skin cancer. This review summarizes the published data on the biological effects of suberythemal exposure using a wide range of clinical, cellular and molecular endpoints, some of which may be considered as biomarkers for skin cancer and photoageing. We also include some recent unpublished results from our laboratories. The effects of UVA (320–400 nm), UVB (290–320 nm) and total solar UVR (290–400 nm) are compared. We demonstrate that avoiding sunburn does not prevent many indicators of cutaneous biological damage and that use of low sun protection factor (SPF) sunscreen can inhibit much of the damages induced by suberythemal exposure to UVR. However, even when applied correctly, sunscreen use will result in suberythemal exposure. The degree and spectral quality of such exposure will depend on the SPF and absorption spectrum of the sunscreen, but nonetheless it may contribute to cumulative photodamage. This review may help to determine the level of photoprotection required in sunscreens and daily use products, as well as the ideal ratio of UVB/UVA protection, to improve long-term photoprotection outcomes. Citing Literature Volume163, Issue5November 2010Pages 903-914 RelatedInformation