A new role for the PI3K/Akt signaling pathway in the epithelial-mesenchymal transition
2015; Landes Bioscience; Volume: 9; Issue: 4 Linguagem: Inglês
10.1080/19336918.2015.1016686
ISSN1933-6926
AutoresWenting Xu, Zhen Yang, Nonghua Lü,
Tópico(s)Hedgehog Signaling Pathway Studies
ResumoTumor metastasis is not only a sign of disease severity but also a major factor causing treatment failure and cancer-related death. Therefore, studies on the molecular mechanisms of tumor metastasis are critical for the development of treatments and for the improvement of survival. The epithelial-mesenchymal transition (EMT) is an orderly, polygenic biological process that plays an important role in tumor cell invasion, metastasis and chemoresistance. The complex, multi-step process of EMT involves multiple regulatory mechanisms. Specifically, the PI3K/Akt signaling pathway can affect the EMT in a variety of ways to influence tumor aggressiveness. A better understanding of the regulatory mechanisms related to the EMT can provide a theoretical basis for the early prediction of tumor progression as well as targeted therapy.
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