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BIBTEX RIS

Trema micrantha toxicity in horses in Brazil

2010; Wiley; Volume: 42; Issue: 5 Linguagem: Inglês

10.1111/j.2042-3306.2010.00035.x

2042-3306

Paulo Mota Bandarra, Saulo Petinatti Pavarini, Djeison Lutier Raymundo, André Mendes Ribeiro Corrêa, Pedro Miguel Ocampos Pedroso, David Driemeier,

Plant-based Medicinal Research

Summary After ingesting green leaves of T. micrantha , 2 horses showed apathy, locomotor deficit, blindness, recumbency, paddling, coma and death. The main gross findings were scattered haemorrhages, enhanced lobular pattern of the liver, and cerebral oedema. Histological changes included disseminated haemorrhages, massive hepatocellular necrosis, neuronal degeneration, Alzheimer type II astrocytes and cerebral perivascular oedema. Clinicopathological findings which were comparable with those observed in Trema micrantha poisoned ruminants, associated with epidemiological evidence suggested the diagnosis. Trema micrantha poisoning should be evaluated as a possible cause in the diagnosis of equine hepatopathy and occasional secondary encephalopathy.