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A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention

2015; Massachusetts Medical Society; Volume: 373; Issue: 17 Linguagem: Inglês

10.1056/nejmoa1506197

1533-4406

Andrew C. Chen, Andrew Martin, Bonita Choy, Pablo Fernández‐Peñas, Robyn A. Dalziell, Catriona McKenzie, Richard A. Scolyer, Haryana M. Dhillon, Janette Vardy, Anne Kricker, Gayathri St George, Niranthari Chinniah, Gary M. Halliday, Diona L. Damian,

Cutaneous lymphoproliferative disorders research

Nonmelanoma skin cancers, such as basal-cell carcinoma and squamous-cell carcinoma, are common cancers that are caused principally by ultraviolet (UV) radiation. Nicotinamide (vitamin B3) has been shown to have protective effects against damage caused by UV radiation and to reduce the rate of new premalignant actinic keratoses.