Sex-related difference in the inductions by perfluoro-octanoic acid of peroxisomal β -oxidation, microsomal 1-acylglycerophosphocholine acyltransferase and cytosolic long-chain acyl-CoA hydrolase in rat liver
1989; Portland Press; Volume: 261; Issue: 2 Linguagem: Inglês
10.1042/bj2610595
ISSN1470-8728
AutoresYoshiaki Kawashimà, Narcisa Uy-Yu, Hiromitsu Kozuka,
Tópico(s)Adipose Tissue and Metabolism
ResumoInductions by perfluoro-octanoic acid (PFOA) of hepatomegaly, peroxisomal beta-oxidation, microsomal 1-acylglycerophosphocholine acyltransferase and cytosolic long-chain acyl-CoA hydrolase were compared in liver between male and female rats. Marked inductions of these four parameters were seen concurrently in liver of male rats, whereas the inductions in liver of female rats were far less pronounced. The sex-related difference in the response of rat liver to PFOA was much more marked than that seen with p-chlorophenoxyisobutyric acid (clofibric acid) or 2,2′-(decamethylenedithio)diethanol (tiadenol). Hormonal manipulations revealed that this sex-related difference in the inductions is strongly dependent on sex hormones, namely that testosterone is necessary for the inductions, whereas oestradiol prevented the inductions by PFOA.
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