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Immunohistochemical study of the expression of fatty acid synthase and Ki-67 in salivary gland tumors
2011; Wiley; Volume: 40; Issue: 6 Linguagem: Inglês
10.1111/j.1600-0714.2011.01023.x
ISSN1600-0714
AutoresRenata Falchete do Prado, Ana Lourdes da Silva Machado, Carlos Eduardo Dias Colombo, Yasmin Rodarte Carvalho,
Tópico(s)Cancer, Hypoxia, and Metabolism
ResumoJournal of Oral Pathology & MedicineVolume 40, Issue 6 p. 467-475 Immunohistochemical study of the expression of fatty acid synthase and Ki-67 in salivary gland tumors Renata Falchete do Prado, Renata Falchete do Prado Department of Physiotherapy, Superior School of Cruzeiro, Cruzeiro, São Paulo, BrazilSearch for more papers by this authorAna Lourdes da Silva Machado, Ana Lourdes da Silva Machado Department of Bioscience and Oral Diagnosis, São José dos Campos Dental School, São Paulo State University, São José dos Campos, São Paulo, BrazilSearch for more papers by this authorCarlos Eduardo Dias Colombo, Carlos Eduardo Dias Colombo Department of Dentistry, University of Taubaté, Taubaté, São Paulo, BrazilSearch for more papers by this authorYasmin Rodarte Carvalho, Yasmin Rodarte Carvalho Department of Bioscience and Oral Diagnosis, São José dos Campos Dental School, São Paulo State University, São José dos Campos, São Paulo, BrazilSearch for more papers by this author Renata Falchete do Prado, Renata Falchete do Prado Department of Physiotherapy, Superior School of Cruzeiro, Cruzeiro, São Paulo, BrazilSearch for more papers by this authorAna Lourdes da Silva Machado, Ana Lourdes da Silva Machado Department of Bioscience and Oral Diagnosis, São José dos Campos Dental School, São Paulo State University, São José dos Campos, São Paulo, BrazilSearch for more papers by this authorCarlos Eduardo Dias Colombo, Carlos Eduardo Dias Colombo Department of Dentistry, University of Taubaté, Taubaté, São Paulo, BrazilSearch for more papers by this authorYasmin Rodarte Carvalho, Yasmin Rodarte Carvalho Department of Bioscience and Oral Diagnosis, São José dos Campos Dental School, São Paulo State University, São José dos Campos, São Paulo, BrazilSearch for more papers by this author First published: 08 March 2011 https://doi.org/10.1111/j.1600-0714.2011.01023.xCitations: 7 Renata Falchete do Prado, PhD, Department of Physiotherapy, Superior School of Cruzeiro, Cruzeiro, Av. Engenheiro Francisco José Longo, 777 Jardim São Dimas, São José dos Campos, CEP 12245000, São Paulo, Brazil. Tel: +55 12 39479035, Fax: +55 12 39479010, E-mail: renatafalchete@hotmail.com Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract J Oral Pathol Med (2010) 40: 467–475 Background: The enzyme fatty acid synthase plays a fundamental role in the biosynthesis of fatty acids. Several recent studies have demonstrated a high fatty acid synthase expression in malignant tumors. Few studies have been conducted in oral and salivary gland tumors describing the fatty acid synthase expression. Methods: This study evaluated and compared, by immunohistochemical reaction, the expression of fatty acid synthase and Ki-67 in salivary gland tumors. The immunohistochemical study used the streptavidin–biotin–peroxidase technique, with antibodies anti-fatty acid synthase and anti-Ki-67. The fatty acid synthase was analyzed by scores, considering the intensity of labeling, quantity of labeled cells and histological component. The Ki-67 was analyzed by counting of one thousand cells, calculating the quantity of positive cells in regions with higher density of labeling. Statistical analysis was performed using the Pearson and Mann–Whitney correlation tests. Results: There was greater fatty acid synthase expression in pleomorphic adenoma compared to other tumors, and predominance of Ki-67 in malignant tumors. Among these, the mucoepidermoid carcinoma presented the highest proliferation rate. The expression of fatty acid synthase and Ki-67 did not present correlation between the tumors analyzed, except in pleomorphic adenomas, with statistically significant relationship between them. Conclusion: It is suggested that the fat metabolism in salivary gland tumors is related to maintenance of cell differentiation. Its expression prevailed in benign tumors, while Ki-67 prevailed in the mucoepidermoid carcinoma, demonstrating its high proliferation rate, followed by the cystic adenoid carcinoma and polymorphous low grade adenocarcinoma. Citing Literature Volume40, Issue6July 2011Pages 467-475 RelatedInformation
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