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The epidemiology of iodine-deficiency disorders in relation to goitrogenic factors and thyroid-stimulating-hormone regulation

1993; Elsevier BV; Volume: 57; Issue: 2 Linguagem: Inglês

10.1093/ajcn/57.2.267s

1938-3207

CH Thilly, Béatrice Swennen, P Bourdoux, K Ntambue, Rodrigo Moreno‐Reyes, J Gillies, JB Vanderpas,

Thyroid Disorders and Treatments

In children aged 5–7 y from goiter-endemic areas in Ubangi, Zaire, and Ntcheu, Malawi, mean serum thyroxin (T4) concentrations were 53 ± 49 vs 81 ±33 nmol/L (P < 0.05), and thyroid-stimulating hormone (TSH) values were 24.3 ± 9.6 vs 4.5 ± 3.3 mU/L respectively (P < 0.01); mean urinary iodine concentrations were 0.14 ± 0.02 vs 0.09 ± 0.02 µmol/L, and mean thiocyanate concentrations were 0.33 ± 0.05 vs 0.17 ± 0.05 nmol/L, respectively (P < 0.05). Mean serum selenium concentrations were 0.343 ± 0.176 µmol/L in Ubangi and 0.437 ± 0.178 µmol/L in Ntcheu (P < 0.05). In two groups of 11 adolescent girls from Ubangi, the mean values for excretion of urinary iodine were 1.31 ±0.14 and 0.58 ±0.17 µmol/L (P < 0.05) after a meal of cassava or a control meal of rice, respectively. In euthyroid subjects from Ubangi, mean serum TSH for a given serum T4 was approximately twice as high for children aged < 15 y than for those aged 16–25 y. The high frequency of myxedematous cretins observed in Ubangi very probably result from both severe iodine and selenium deficiency together with thiocyanate overload.