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Artigo Produção Nacional Revisado por pares
BIBTEX RIS

Fish oil reduces the proliferation of cells cultured from human breast and colorectal tumours: An in vitro study

2015; Elsevier BV; Volume: 19; Linguagem: Inglês

10.1016/j.jff.2015.09.025

ISSN

2214-9414

Autores

Sandro José Ribeiro Bonatto, Adriana Yamaguchi, Isabela Coelho, Everson Araújo Nunes, Fabíola Iagher, Jorge Itsuo Fukushima, Luciano V. Sabóia, Luiz Cláudio Fernandes,

Tópico(s)

Lipid metabolism and biosynthesis

Resumo

Diet plays a key role in the aetiology of cancer. Some studies have shown that diets rich in n-3 polyunsaturated fatty acids (n-3 PUFA) reduce tumour growth. This study aimed to investigate the effects of fish oil, rich in n-3 PUFA, in cell proliferation and death of cells from breast and colorectal tumours. In the presence of 1:5 (v/v) dilution of fish oil, 1.8-fold reduction in cell proliferation (p < 0.05) was observed. In addition, the presence of fish oil at a 1:5 proportion led to 1.6-fold increase in the rate of apoptosis, 6.7-fold increase in hydroperoxides, and 5-fold reduction in necrosis (p < 0.0001).

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