Produção Nacional
Revisado por pares
Osmotic and morphological effects on red blood cell membrane: action of an aqueous extract of Lantana camara
2008; Springer Science+Business Media; Volume: 18; Issue: 1 Linguagem: Inglês
10.1590/s0102-695x2008000100010
ISSN1981-528X
AutoresAdalgisa Ieda Maiworm, G. Presta, Sebastião David Santos-Filho, Severo de Paoli, Tânia Santos Giani, Adenilson de Souza da Fonseca, Mário Bernardo-Filho,
Tópico(s)Complementary and Alternative Medicine Studies
ResumoThe Lantana camara ("cambara de espinho") leaves infusions are used popularly in some countries to treat gastrointestinal diseases. Osmotic fragility assay and morphometric analysis have been used to verify the interaction of drugs with the membrane of red blood cells (RBC). The aim of this work was to evaluate the effects of an aqueous extract of Lantana camara on the osmotic fragility and on the morphology of RBC. Blood samples were treated with extract of Lantana camara (10 mg/mL), osmotic fragility assay and morphological analysis were carried out. In the presence of the extract, the data obtained indicated (i) a significant (p < 0.05) increase of hemolysis and (ii) modifications on the morphology of RBC. These effects of the Lantana camara may be associated with some pharmacological properties of the chemical compounds of this studied extract.
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