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Studies of the Effect of X-Rays on Glandular Activity

1923; Radiological Society of North America; Volume: 1; Issue: 1 Linguagem: Inglês

10.1148/1.1.39

1527-1315

A. C. Ivy, Benjamin H. Orndoff, Arie S. Jacoby, J. E. Whitlow,

Nutrition, Genetics, and Disease

In a previous communication (1) we have presented evidence showing that the secretion of the submaxillary gland in the dog cannot be stimulated by small doses of X-rays and that a dose of 110 K.V.M., 10 ma., 30 cm. f. s. d., 28 cm.2 portal, 1 mm. Al. filter for 37 minutes is required to depress its secretory activity. This dosage amounts to two "dog erythema doses," or five "human erythema doses," since we have found that the dog's skin is from two and one-half to three times less sensitive than the skin of man.2 The submaxillary gland was selected as the first gland for our study because much is known concerning its physiology and because it lends itself so readily to experimentation. We have chosen the gastric glands as the second gland for study for the same reasons. A review of the literature shows that no experimental work has been done on the effect of X-rays on gastric secretion. Rcgaud, Nogier and Lacassogne (2) working in 1912, report that the glands of the fundic portion of the stomach were found to have undergone complete atrophy in a dog which had been exposed to a total of 63 H. (3 doses of 9 H. with 2 mm. Al. filter, 1 dose of 14 H. with 3 mm. Al. filter, and 1 dose of 22 H. with 4 mm. Al. filter) given in five doses over a course of fifteen months. They made no observations on the gastric secretion of this dog. There arc several clinical reports, however, stating that X-ray has been used with beneficial therapeutic results in hyperacidity. Winternitz (3), in 1910, reported that radium even in relatively large doses in radioactive water (4000 mache-einheit, or 400,000 volt-abfalleinheiter) has no influence on gastric secretion. Bruegcl (4), making observations on ninety cases, reports that the acidity of the gastric secretion is reduced when exposed to 16 to 20 H., using a filter of 3 mm. Al. and 1½ mm. of hard rubber and a 30 cm. focal skin distance. He administered 4-5 II. anteriorly and posteriorly over the stomach and then-in fourteen days repeated the dose. He attempted to stimulate the gastric glands in cases of hypo- and anacidity by using stimulating doses of X-ray (he does not give the doses used) with negative results. Wilms (5) in a very brief report states that in certain cases of pylorospàsm X-rays have a beneficial therapeutic effect, which he explains as due to the reduction of the acidity of the gastric secretion. Steph-an (6) reports a case of achylia gastro-pancreation which on being irradiated with one-tenth of an erythema dose showed improvement in the pancreatic deficiency without any change in the achylia gastrica. Szego and Rother (7) state that they could influence gastric secretion only with a dose greater than an erythema dose and that when this was done they observed, first, a stimulation, followed by a depression of gastric secretion.