Anxiety and congenital central hypoventilation syndrome
1994; American Psychiatric Association; Volume: 151; Issue: 6 Linguagem: Inglês
10.1176/ajp.151.6.864
ISSN1535-7228
AutoresDaniel S. Pine, Debra E. Weese‐Mayer, Jean M. Silvestri, Mary‐Ann Davies, Agnes H. Whitaker, D F Klein,
Tópico(s)Adolescent and Pediatric Healthcare
ResumoBack to table of contents Previous article Next article No AccessAnxiety and congenital central hypoventilation syndromePublished Online:1 Apr 2006https://doi.org/10.1176/ajp.151.6.864AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractOBJECTIVE: It has been hypothesized that individuals who cannot perceive elevations of CO2 will be less anxious than individuals with intact CO2 perception. To test this hypothesis, children with congenital central hypoventilation syndrome, who have a potentially lethal chronic illness associated with lack of CO2 perception and thus provide a natural experimental group, were studied. METHOD: Rates of anxiety symptoms and disorders in children with congenital central hypoventilation syndrome (N = 13) were compared with rates in an age- matched, nonreferred group of community subjects (N = 292) that included subgroups of children with asthma (N = 15) and other chronic medical illnesses (N = 66). Anxiety symptoms were assessed with information obtained from structured interviews of the parents, which provided both total symptom scores and DSM-III-R diagnoses. RESULTS: The children with congenital central hypoventilation syndrome exhibited significantly fewer anxiety symptoms than all other comparison subjects. Two of these children (15%) met criteria for anxiety disorders, a rate lower than that of the whole community group (24%) and of the chronically ill comparison subgroups (32%-47%). The largest difference in the prevalence of disorder emerged between the children with congenital central hypoventilation syndrome (15%) and those with asthma (47%). In the comparison of children with congenital central hypoventilation syndrome and children with other chronic illnesses, a priori analysis showed that the former had significantly lower rates of disorders that have been linked to panic in the literature. CONCLUSIONS: This study supports theories of anxiety that implicate CO2 perception in the pathophysiology of panic and related anxiety states. Access content To read the fulltext, please use one of the options below to sign in or purchase access. Personal login Institutional Login Sign in via OpenAthens Purchase Save for later Item saved, go to cart PPV Articles - American Journal of Psychiatry $35.00 Add to cart PPV Articles - American Journal of Psychiatry Checkout Please login/register if you wish to pair your device and check access availability. Not a subscriber? Subscribe Now / Learn More PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development. Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.). FiguresReferencesCited byDetailsCited byGuidelines for diagnosis and management of congenital central hypoventilation syndrome21 September 2020 | Orphanet Journal of Rare Diseases, Vol. 15, No. 1Neonatal Congenital Central Hypoventilation Syndrome: Why We Should not Sleep on it. Literature Review of Forty-two Neonatal Onset CasesCurrent Pediatric Reviews, Vol. 15, No. 3Sleep in Psychiatric Disorders3 May 2017Pediatric Research, Vol. 81, No. 1-2, Vol. 209Respiratory Physiology & Neurobiology, Vol. 185, No. 1Revue des Maladies Respiratoires, Vol. 30, No. 8Elucidation of neurobiology of anxiety disorders in children through pharmacological challenge tests and cortisol measurements: a systematic review19 July 2010 | Journal of Psychopharmacology, Vol. 26, No. 4Variable human phenotype associated with novel deletions of the PHOX2B gene9 August 2011 | Pediatric Pulmonology, Vol. 47, No. 2American Journal of Medical Genetics Part A, Vol. 158A, No. 9, Vol. 106Revista Brasileira de Psiquiatria, Vol. 34Opioids and anxiety8 June 2010 | Journal of Psychopharmacology, Vol. 25, No. 11An Official ATS Clinical Policy Statement: Congenital Central Hypoventilation SyndromeAmerican Journal of Respiratory and Critical Care Medicine, Vol. 181, No. 6Novel neuropathologic findings in the Haddad syndrome21 October 2009 | Acta Neuropathologica, Vol. 119, No. 2Congenital central hypoventilation syndrome: Neurocognitive functioning in school age children3 December 2009 | Pediatric Pulmonology, Vol. 45, No. 1Respiratory Physiology & Neurobiology, Vol. 173, No. 3Journal of Applied Physiology, Vol. 108, No. 4Congenital central hypoventilation syndrome from past to future: Model for translational and transitional autonomic medicine6 May 2009 | Pediatric Pulmonology, Vol. 44, No. 6Sleep in Psychiatric DisordersRespiratory Physiology & Neurobiology, Vol. 167, No. 1Journal of Anxiety Disorders, Vol. 22, No. 1Journal of Psychiatric Research, Vol. 42, No. 10Sleep Medicine Clinics, Vol. 3, No. 2Sleep Medicine Clinics, Vol. 3, No. 4Respiratory Physiology & Neurobiology, Vol. 164, No. 1-2Pediatric Autonomic Disorders1 July 2006 | Pediatrics, Vol. 118, No. 1Current Psychiatry Reports, Vol. 7, No. 4Child and Adolescent Psychiatric Clinics of North America, Vol. 14, No. 4Neuroscience & Biobehavioral Reviews, Vol. 29, No. 1Respiratory Physiology & Neurobiology, Vol. 149, No. 1-3Pediatric Research, Vol. 57, No. 4Pediatric Research, Vol. 57, No. 4Anxiety and Depression in Patients With Pulmonary HypertensionPsychosomatic Medicine, Vol. 66, No. 6Cognitive and Behavioral Practice, Vol. 11, No. 1Australian Occupational Therapy Journal, Vol. 51, No. 4Journal of Psychosomatic Research, Vol. 55, No. 3Allergologia et Immunopathologia, Vol. 31, No. 5Journal of the American Academy of Child & Adolescent Psychiatry, Vol. 41, No. 5Chest, Vol. 122, No. 2Covert fears and anxiety in asthma and congenital heart disease 112 January 2002 | Child: Care, Health and Development, Vol. 27, No. 4Idiopathic Congenital Central Hypoventilation SyndromeAmerican Journal of Respiratory and Critical Care Medicine, Vol. 160, No. 1Assessment of Psychopathology: Nosology and EtiologyJournal of Anxiety Disorders, Vol. 12, No. 5Journal of the American Academy of Child & Adolescent Psychiatry, Vol. 37, No. 9Association of Panic Disorder With a History of Traumatic SuffocationColin Bouwer, M.B., and Dan J. Stein, M.B.1 April 2006 | American Journal of Psychiatry, Vol. 154, No. 11Discriminating depression and anxiety in youth: A role for diagnostic criteriaJournal of Affective Disorders, Vol. 39, No. 3Neuron, Vol. 17, No. 4Journal of the American Academy of Child & Adolescent Psychiatry, Vol. 35, No. 8 Volume 151Issue 6 June 1994Pages 864-870 Metrics PDF download History Published online 1 April 2006 Published in print 1 June 1994
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