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Accuracy and Acceptability of Oral Fluid HIV Self-Testing in a General Adult Population in Kenya

2015; Springer Science+Business Media; Volume: 20; Issue: 4 Linguagem: Inglês

10.1007/s10461-015-1213-9

1573-3254

Ann Kurth, Charles M. Cleland, Nok Chhun, John E. Sidle, Edwin Were, Violet Naanyu, Wilfred Emonyi, Stephen Macharia, Edwin Sang, Abraham Siika,

HIV/AIDS oral health manifestations

We evaluated performance, accuracy, and acceptability parameters of unsupervised oral fluid (OF) HIV self-testing (HIVST) in a general population in western Kenya. In a prospective validation design, we enrolled 240 adults to perform rapid OF HIVST and compared results to staff administered OF and rapid fingerstick tests. All reactive, discrepant, and a proportion of negative results were confirmed with lab ELISA. Twenty participants were video-recorded conducting self-testing. All participants completed a staff administered survey before and after HIVST to assess attitudes towards OF HIVST acceptability. HIV prevalence was 14.6 %. Thirty-six of the 239 HIVSTs were invalid (15.1 %; 95 % CI 11.1-20.1 %), with males twice as likely to have invalid results as females. HIVST sensitivity was 89.7 % (95 % CI 73-98 %) and specificity was 98 % (95 % CI 89-99 %). Although sensitivity was somewhat lower than expected, there is clear interest in, and high acceptability (94 %) of OF HIV self-testing.