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FOLIC ACID ACTIVITY IN LEUKEMIA AND CANCER.

1965; National Institutes of Health; Volume: 25; Linguagem: Inglês

Rao Pb, B Lagerloef, J. Einhorn, Reizenstein Pg,

Acute Lymphoblastic Leukemia research

Summary The serum folic acid activity (SFAA) was measured using Lactobacillus casei as the test organism. The SFAA was lower for patients with malignant tumors than for the control group. The lowest values were for malignant lymphoma and leukemia. No relation was found between the SFAA and either the spread of the tumors, the therapy administered, the age of the patient or the degree of wasting. Although the SFAA was significantly lowered in leukemia, the folic acid activity (FAA) was higher in white cells of such patients than in those of healthy controls. The FAA was also determined in chicks during development of virus-induced leukemia.