Programmed cell death is affected in the novel mouse mutant Fused toes (Ft)
1994; The Company of Biologists; Volume: 120; Issue: 9 Linguagem: Inglês
10.1242/dev.120.9.2601
ISSN1477-9129
AutoresF. van der Hoeven, Thomas Schimmang, Ariane Volkmann, Marie‐Geneviève Mattéi, Bruno Kyewski, Ulrich Rüther,
Tópico(s)Developmental Biology and Gene Regulation
ResumoABSTRACT We have identified a novel dominant mouse mutant that is characterised by fused toes on the fore limbs and a thymic hyperplasia, in heterozygous animals. Homozygosity of the mutation leads to malformation of the developing brain, lost of the genetic control of left-right asymmetry and to death around day 10 of development. Analysis of both limb development and induction of apoptosis in immature thymocytes in vitro suggest that programmed cell death is affected by the mutation. Since the mutation was causedvia a transgene insertion we were able to map it to the D region on mouse chromosome 8. So far, no mutation that affects programmed cell death has been mapped to this chromosome. Thus, this mutation will allow the identification of a novel gene involved in programmed cell death during mammalian development.
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