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Translocation (1;16) identified by chromosome painting, and PRimed IN Situ-labeling (PRINS)

1995; Elsevier BV; Volume: 79; Issue: 1 Linguagem: Inglês

10.1016/0165-4608(94)00102-h

1873-4456

Johnny Hindkjær, Sahar A.F.M. Hammoudah, Knud Bendix Hansen, Peter D. Ørberg Jensen, Jørn Koch, Bent Pedersen,

DNA Repair Mechanisms

We used the molecular cytogenetic in situ techniques chromosome painting and PRimed IN Situ labeling (PRINS) to elaborate the cytogenetic observations in two cases of the rare aberration der(16)6(1;16), which occurs in a wide variation of hematologic and nonhematologic malignancies [1–13]. Review of the literature showed that, in contrast to the chromosome 1 breakpoint, the breakpoint on chromosome 16 is associated with diagnosis as well as patient age.