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Epidemiology of invasive fungal diseases among patients with haematological disorders in the Asia-Pacific: a prospective observational study

2015; Elsevier BV; Volume: 21; Issue: 6 Linguagem: Inglês

10.1016/j.cmi.2015.02.019

1469-0691

Li Yang Hsu, Dong‐Gun Lee, S.-P. Yeh, Dinesh Bhurani, Bạch Quốc Khánh Khanh, Chian Yong Low, Lalita Norasetthada, Tak Mao Chan, Yok–Lam Kwong, Ashok Vaid, I. Alejandria, M. Mendoza, Chien‐Yi Chen, Andrew S. Johnson, Thean Yen Tan,

Neutropenia and Cancer Infections

We conducted a 2-year multicentre prospective observational study to determine the epidemiology of and mortality associated with invasive fungal diseases (IFDs) among patients with haematological disorders in Asia. Eleven institutions from 8 countries/regions participated, with 412 subjects (28.2% possible, 38.3% probable and 33.5% proven IFDs) recruited. The epidemiology of IFDs in participating institutions was similar to Western centres, with Aspergillus spp. (65.9%) or Candida spp. (26.7%) causing the majority of probable and proven IFDs. The overall 30-day mortality was 22.1%. Progressive haematological disorder (odds ratio [OR] 5.192), invasive candidiasis (OR 3.679), and chronic renal disease (OR 6.677) were independently associated with mortality.