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Management of a pemphigus with IgA and IgG antibodies and coexistent lung cancer

2014; Wiley; Volume: 27; Issue: 4 Linguagem: Inglês

10.1111/dth.12126

1529-8019

Petra Cetkovská, Michaela Komorousová, Iva Lomicová,

Coagulation, Bradykinin, Polyphosphates, and Angioedema

Dermatologic TherapyVolume 27, Issue 4 p. 236-239 Therapeutic Hotline Management of a pemphigus with IgA and IgG antibodies and coexistent lung cancer Petra Cetkovská, Corresponding Author Petra Cetkovská Medical Faculty and Teaching Hospital Pilsen, Department of Dermatology and Venereology, Charles University, Pilsen, Czech RepublicAddress correspondence and reprint requests to: Petra Cetkovská, MD, PhD, Professor, Medical Faculty and Teaching Hospital Pilsen, Department of Dermatology and Venereology, Charles University, Dr. Edvarda Beneše 13, 30599 Pilsen, Czech Republic, or e-mail: cetkovska@fnplzen.cz.Search for more papers by this authorMichaela Komorousová, Michaela Komorousová Medical Faculty and Teaching Hospital Pilsen, Department of Dermatology and Venereology, Charles University, Pilsen, Czech RepublicSearch for more papers by this authorIva Lomicová, Iva Lomicová Medical Faculty and Teaching Hospital Pilsen, Department of Dermatology and Venereology, Charles University, Pilsen, Czech RepublicSearch for more papers by this author Petra Cetkovská, Corresponding Author Petra Cetkovská Medical Faculty and Teaching Hospital Pilsen, Department of Dermatology and Venereology, Charles University, Pilsen, Czech RepublicAddress correspondence and reprint requests to: Petra Cetkovská, MD, PhD, Professor, Medical Faculty and Teaching Hospital Pilsen, Department of Dermatology and Venereology, Charles University, Dr. Edvarda Beneše 13, 30599 Pilsen, Czech Republic, or e-mail: cetkovska@fnplzen.cz.Search for more papers by this authorMichaela Komorousová, Michaela Komorousová Medical Faculty and Teaching Hospital Pilsen, Department of Dermatology and Venereology, Charles University, Pilsen, Czech RepublicSearch for more papers by this authorIva Lomicová, Iva Lomicová Medical Faculty and Teaching Hospital Pilsen, Department of Dermatology and Venereology, Charles University, Pilsen, Czech RepublicSearch for more papers by this author First published: 22 April 2014 https://doi.org/10.1111/dth.12126Citations: 8Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Immunoglobulin A (IgA) pemphigus is a clinically distinct variant of pemphigus characterized by intercellular IgA deposition in the epidermis. Recently, an IgA/Immunoglobulin G (IgG) subset of pemphigus with IgA and IgG anti-keratinocyte cell surface antibodies has been described. Both IgA and IgA/IgG pemphigus have been associated with internal malignancies. Above all, monoclonal IgA gammopathy in patients with IgA pemphigus has been reported, and lung cancers in association with IgA/IgG pemphigus have been described. IgA pemphigus can be successfully treated with dapsone, whereas therapeutic management of IgG/IgA pemphigus is not well established yet. We report a rare case of a patient, who developed atypical pemphigus with both IgA and IgG autoantibodies and an underlying lung cancer, successfully treated with corticosteroids and dapsone. Citing Literature Volume27, Issue4July/August 2014Pages 236-239 RelatedInformation