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Muscle hypertrophy with large-scale weight loss and resistance training

1993; Elsevier BV; Volume: 58; Issue: 4 Linguagem: Inglês

10.1093/ajcn/58.4.561

1938-3207

JE Donnelly, T Sharp, Joseph A. Houmard, M. P. Carlson, JO Hill, JE Whatley, RG Israel,

Muscle Physiology and Disorders

The combined effects of exercise and energy restriction on changes in body fat and fat-free mass (FFM) are controversial. This study was conducted to determine whether muscle hypertrophy is possible during weight loss. Fourteen obese females received a 3360-kJ/d liquid diet for 90 d. Seven subjects received a weight training (WT) regimen and seven subjects remained sedentary (C). Biopsy samples were obtained from the vastus lateralis muscle at baseline and after 90 d of treatment. The average weight loss over the 90-d period was 16 kg with ≈ 24% of the weight loss from FFM and 76% from fat. The amount and composition of the weight loss did not differ between WT and C groups. The cross-sectional area of slow twitch and fast twitch fibers was unchanged by treatment in C subjects but significantly increased in WT subjects. It appears that weight training can produce hypertrophy in skeletal muscle during severe energy restriction and large-scale weight loss.