Imaging in StrokeNet
2015; Lippincott Williams & Wilkins; Volume: 46; Issue: 7 Linguagem: Tagalog
10.1161/strokeaha.115.009479
ISSN1524-4628
AutoresDavid S. Liebeskind, Gregory W. Albers, Karen Crawford, Colin P. Derdeyn, Mark S. George, Yuko Y. Palesch, Arthur W. Toga, Steven Warach, Wenle Zhao, Thomas Brott, Ralph L. Sacco, Pooja Khatri, Jeffrey L. Saver, Steven C. Cramer, Steven L. Wolf, Joseph P. Broderick, Max Wintermark,
Tópico(s)Stroke Rehabilitation and Recovery
ResumoHomeStrokeVol. 46, No. 7Imaging in StrokeNet Free AccessResearch ArticlePDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessResearch ArticlePDF/EPUBImaging in StrokeNetRealizing the Potential of Big Data David S. Liebeskind, MD, Gregory W. Albers, MD, Karen Crawford, MLIS, Colin P. Derdeyn, MD, Mark S. George, MD, Yuko Y. Palesch, PhD, Arthur W. Toga, PhD, Steven Warach, MD, Wenle Zhao, PhD, Thomas G. Brott, MD, Ralph L. Sacco, MD, MS, Pooja Khatri, MD, MSc, Jeffrey L. Saver, MD, Steven C. Cramer, MD, Steven L. Wolf, PhD, Joseph P. Broderick, MD and Max Wintermark, MD David S. LiebeskindDavid S. Liebeskind From the Neurovascular Imaging Research Core (D.S.L.) and Department of Neurology, Comprehensive Stroke Center, Geffen School of Medicine (D.S.L., J.L.S.), University of California, Los Angeles; Departments of Neurology (G.W.A.) and Radiology (M.W.), Stanford University, Palo Alto, CA; Laboratory of Neuro Imaging, Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles (K.C., A.W.T.); Departments of Neurology and Neurological Surgery, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO (C.P.D.); Departments of Psychiatry, Radiology, and Neuroscience (M.S.G.) and Public Health Sciences (Y.Y.P., W.Z.), Medical University of South Carolina, Charleston; Ralph H Johnson VA Medical Center, Charleston, SC (M.S.G.); University of Texas Southwestern Medical Center, Austin (S.W.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Departments of Neurology, Public Health Sciences, Human Genetics, and Neurosurgery, Miller School of Medicine, University of Miami, FL (R.L.S.); Department of Neurology, University of Cincinnati, OH (P.K., J.P.B.); Department of Neurology, University of California, Irvine (S.C.C.); and Department of Rehabilitation Medicine, Emory University School of Medicine and Center for Visual and Cognitive Neurorehabilitation, Atlanta VA Medical Center, GA (S.L.W.). , Gregory W. AlbersGregory W. Albers From the Neurovascular Imaging Research Core (D.S.L.) and Department of Neurology, Comprehensive Stroke Center, Geffen School of Medicine (D.S.L., J.L.S.), University of California, Los Angeles; Departments of Neurology (G.W.A.) and Radiology (M.W.), Stanford University, Palo Alto, CA; Laboratory of Neuro Imaging, Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles (K.C., A.W.T.); Departments of Neurology and Neurological Surgery, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO (C.P.D.); Departments of Psychiatry, Radiology, and Neuroscience (M.S.G.) and Public Health Sciences (Y.Y.P., W.Z.), Medical University of South Carolina, Charleston; Ralph H Johnson VA Medical Center, Charleston, SC (M.S.G.); University of Texas Southwestern Medical Center, Austin (S.W.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Departments of Neurology, Public Health Sciences, Human Genetics, and Neurosurgery, Miller School of Medicine, University of Miami, FL (R.L.S.); Department of Neurology, University of Cincinnati, OH (P.K., J.P.B.); Department of Neurology, University of California, Irvine (S.C.C.); and Department of Rehabilitation Medicine, Emory University School of Medicine and Center for Visual and Cognitive Neurorehabilitation, Atlanta VA Medical Center, GA (S.L.W.). , Karen CrawfordKaren Crawford From the Neurovascular Imaging Research Core (D.S.L.) and Department of Neurology, Comprehensive Stroke Center, Geffen School of Medicine (D.S.L., J.L.S.), University of California, Los Angeles; Departments of Neurology (G.W.A.) and Radiology (M.W.), Stanford University, Palo Alto, CA; Laboratory of Neuro Imaging, Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles (K.C., A.W.T.); Departments of Neurology and Neurological Surgery, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO (C.P.D.); Departments of Psychiatry, Radiology, and Neuroscience (M.S.G.) and Public Health Sciences (Y.Y.P., W.Z.), Medical University of South Carolina, Charleston; Ralph H Johnson VA Medical Center, Charleston, SC (M.S.G.); University of Texas Southwestern Medical Center, Austin (S.W.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Departments of Neurology, Public Health Sciences, Human Genetics, and Neurosurgery, Miller School of Medicine, University of Miami, FL (R.L.S.); Department of Neurology, University of Cincinnati, OH (P.K., J.P.B.); Department of Neurology, University of California, Irvine (S.C.C.); and Department of Rehabilitation Medicine, Emory University School of Medicine and Center for Visual and Cognitive Neurorehabilitation, Atlanta VA Medical Center, GA (S.L.W.). , Colin P. DerdeynColin P. Derdeyn From the Neurovascular Imaging Research Core (D.S.L.) and Department of Neurology, Comprehensive Stroke Center, Geffen School of Medicine (D.S.L., J.L.S.), University of California, Los Angeles; Departments of Neurology (G.W.A.) and Radiology (M.W.), Stanford University, Palo Alto, CA; Laboratory of Neuro Imaging, Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles (K.C., A.W.T.); Departments of Neurology and Neurological Surgery, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO (C.P.D.); Departments of Psychiatry, Radiology, and Neuroscience (M.S.G.) and Public Health Sciences (Y.Y.P., W.Z.), Medical University of South Carolina, Charleston; Ralph H Johnson VA Medical Center, Charleston, SC (M.S.G.); University of Texas Southwestern Medical Center, Austin (S.W.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Departments of Neurology, Public Health Sciences, Human Genetics, and Neurosurgery, Miller School of Medicine, University of Miami, FL (R.L.S.); Department of Neurology, University of Cincinnati, OH (P.K., J.P.B.); Department of Neurology, University of California, Irvine (S.C.C.); and Department of Rehabilitation Medicine, Emory University School of Medicine and Center for Visual and Cognitive Neurorehabilitation, Atlanta VA Medical Center, GA (S.L.W.). , Mark S. GeorgeMark S. George From the Neurovascular Imaging Research Core (D.S.L.) and Department of Neurology, Comprehensive Stroke Center, Geffen School of Medicine (D.S.L., J.L.S.), University of California, Los Angeles; Departments of Neurology (G.W.A.) and Radiology (M.W.), Stanford University, Palo Alto, CA; Laboratory of Neuro Imaging, Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles (K.C., A.W.T.); Departments of Neurology and Neurological Surgery, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO (C.P.D.); Departments of Psychiatry, Radiology, and Neuroscience (M.S.G.) and Public Health Sciences (Y.Y.P., W.Z.), Medical University of South Carolina, Charleston; Ralph H Johnson VA Medical Center, Charleston, SC (M.S.G.); University of Texas Southwestern Medical Center, Austin (S.W.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Departments of Neurology, Public Health Sciences, Human Genetics, and Neurosurgery, Miller School of Medicine, University of Miami, FL (R.L.S.); Department of Neurology, University of Cincinnati, OH (P.K., J.P.B.); Department of Neurology, University of California, Irvine (S.C.C.); and Department of Rehabilitation Medicine, Emory University School of Medicine and Center for Visual and Cognitive Neurorehabilitation, Atlanta VA Medical Center, GA (S.L.W.). , Yuko Y. PaleschYuko Y. Palesch From the Neurovascular Imaging Research Core (D.S.L.) and Department of Neurology, Comprehensive Stroke Center, Geffen School of Medicine (D.S.L., J.L.S.), University of California, Los Angeles; Departments of Neurology (G.W.A.) and Radiology (M.W.), Stanford University, Palo Alto, CA; Laboratory of Neuro Imaging, Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles (K.C., A.W.T.); Departments of Neurology and Neurological Surgery, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO (C.P.D.); Departments of Psychiatry, Radiology, and Neuroscience (M.S.G.) and Public Health Sciences (Y.Y.P., W.Z.), Medical University of South Carolina, Charleston; Ralph H Johnson VA Medical Center, Charleston, SC (M.S.G.); University of Texas Southwestern Medical Center, Austin (S.W.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Departments of Neurology, Public Health Sciences, Human Genetics, and Neurosurgery, Miller School of Medicine, University of Miami, FL (R.L.S.); Department of Neurology, University of Cincinnati, OH (P.K., J.P.B.); Department of Neurology, University of California, Irvine (S.C.C.); and Department of Rehabilitation Medicine, Emory University School of Medicine and Center for Visual and Cognitive Neurorehabilitation, Atlanta VA Medical Center, GA (S.L.W.). , Arthur W. TogaArthur W. Toga From the Neurovascular Imaging Research Core (D.S.L.) and Department of Neurology, Comprehensive Stroke Center, Geffen School of Medicine (D.S.L., J.L.S.), University of California, Los Angeles; Departments of Neurology (G.W.A.) and Radiology (M.W.), Stanford University, Palo Alto, CA; Laboratory of Neuro Imaging, Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles (K.C., A.W.T.); Departments of Neurology and Neurological Surgery, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO (C.P.D.); Departments of Psychiatry, Radiology, and Neuroscience (M.S.G.) and Public Health Sciences (Y.Y.P., W.Z.), Medical University of South Carolina, Charleston; Ralph H Johnson VA Medical Center, Charleston, SC (M.S.G.); University of Texas Southwestern Medical Center, Austin (S.W.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Departments of Neurology, Public Health Sciences, Human Genetics, and Neurosurgery, Miller School of Medicine, University of Miami, FL (R.L.S.); Department of Neurology, University of Cincinnati, OH (P.K., J.P.B.); Department of Neurology, University of California, Irvine (S.C.C.); and Department of Rehabilitation Medicine, Emory University School of Medicine and Center for Visual and Cognitive Neurorehabilitation, Atlanta VA Medical Center, GA (S.L.W.). , Steven WarachSteven Warach From the Neurovascular Imaging Research Core (D.S.L.) and Department of Neurology, Comprehensive Stroke Center, Geffen School of Medicine (D.S.L., J.L.S.), University of California, Los Angeles; Departments of Neurology (G.W.A.) and Radiology (M.W.), Stanford University, Palo Alto, CA; Laboratory of Neuro Imaging, Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles (K.C., A.W.T.); Departments of Neurology and Neurological Surgery, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO (C.P.D.); Departments of Psychiatry, Radiology, and Neuroscience (M.S.G.) and Public Health Sciences (Y.Y.P., W.Z.), Medical University of South Carolina, Charleston; Ralph H Johnson VA Medical Center, Charleston, SC (M.S.G.); University of Texas Southwestern Medical Center, Austin (S.W.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Departments of Neurology, Public Health Sciences, Human Genetics, and Neurosurgery, Miller School of Medicine, University of Miami, FL (R.L.S.); Department of Neurology, University of Cincinnati, OH (P.K., J.P.B.); Department of Neurology, University of California, Irvine (S.C.C.); and Department of Rehabilitation Medicine, Emory University School of Medicine and Center for Visual and Cognitive Neurorehabilitation, Atlanta VA Medical Center, GA (S.L.W.). , Wenle ZhaoWenle Zhao From the Neurovascular Imaging Research Core (D.S.L.) and Department of Neurology, Comprehensive Stroke Center, Geffen School of Medicine (D.S.L., J.L.S.), University of California, Los Angeles; Departments of Neurology (G.W.A.) and Radiology (M.W.), Stanford University, Palo Alto, CA; Laboratory of Neuro Imaging, Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles (K.C., A.W.T.); Departments of Neurology and Neurological Surgery, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO (C.P.D.); Departments of Psychiatry, Radiology, and Neuroscience (M.S.G.) and Public Health Sciences (Y.Y.P., W.Z.), Medical University of South Carolina, Charleston; Ralph H Johnson VA Medical Center, Charleston, SC (M.S.G.); University of Texas Southwestern Medical Center, Austin (S.W.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Departments of Neurology, Public Health Sciences, Human Genetics, and Neurosurgery, Miller School of Medicine, University of Miami, FL (R.L.S.); Department of Neurology, University of Cincinnati, OH (P.K., J.P.B.); Department of Neurology, University of California, Irvine (S.C.C.); and Department of Rehabilitation Medicine, Emory University School of Medicine and Center for Visual and Cognitive Neurorehabilitation, Atlanta VA Medical Center, GA (S.L.W.). , Thomas G. BrottThomas G. Brott From the Neurovascular Imaging Research Core (D.S.L.) and Department of Neurology, Comprehensive Stroke Center, Geffen School of Medicine (D.S.L., J.L.S.), University of California, Los Angeles; Departments of Neurology (G.W.A.) and Radiology (M.W.), Stanford University, Palo Alto, CA; Laboratory of Neuro Imaging, Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles (K.C., A.W.T.); Departments of Neurology and Neurological Surgery, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO (C.P.D.); Departments of Psychiatry, Radiology, and Neuroscience (M.S.G.) and Public Health Sciences (Y.Y.P., W.Z.), Medical University of South Carolina, Charleston; Ralph H Johnson VA Medical Center, Charleston, SC (M.S.G.); University of Texas Southwestern Medical Center, Austin (S.W.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Departments of Neurology, Public Health Sciences, Human Genetics, and Neurosurgery, Miller School of Medicine, University of Miami, FL (R.L.S.); Department of Neurology, University of Cincinnati, OH (P.K., J.P.B.); Department of Neurology, University of California, Irvine (S.C.C.); and Department of Rehabilitation Medicine, Emory University School of Medicine and Center for Visual and Cognitive Neurorehabilitation, Atlanta VA Medical Center, GA (S.L.W.). , Ralph L. SaccoRalph L. Sacco From the Neurovascular Imaging Research Core (D.S.L.) and Department of Neurology, Comprehensive Stroke Center, Geffen School of Medicine (D.S.L., J.L.S.), University of California, Los Angeles; Departments of Neurology (G.W.A.) and Radiology (M.W.), Stanford University, Palo Alto, CA; Laboratory of Neuro Imaging, Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles (K.C., A.W.T.); Departments of Neurology and Neurological Surgery, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO (C.P.D.); Departments of Psychiatry, Radiology, and Neuroscience (M.S.G.) and Public Health Sciences (Y.Y.P., W.Z.), Medical University of South Carolina, Charleston; Ralph H Johnson VA Medical Center, Charleston, SC (M.S.G.); University of Texas Southwestern Medical Center, Austin (S.W.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Departments of Neurology, Public Health Sciences, Human Genetics, and Neurosurgery, Miller School of Medicine, University of Miami, FL (R.L.S.); Department of Neurology, University of Cincinnati, OH (P.K., J.P.B.); Department of Neurology, University of California, Irvine (S.C.C.); and Department of Rehabilitation Medicine, Emory University School of Medicine and Center for Visual and Cognitive Neurorehabilitation, Atlanta VA Medical Center, GA (S.L.W.). , Pooja KhatriPooja Khatri From the Neurovascular Imaging Research Core (D.S.L.) and Department of Neurology, Comprehensive Stroke Center, Geffen School of Medicine (D.S.L., J.L.S.), University of California, Los Angeles; Departments of Neurology (G.W.A.) and Radiology (M.W.), Stanford University, Palo Alto, CA; Laboratory of Neuro Imaging, Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles (K.C., A.W.T.); Departments of Neurology and Neurological Surgery, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO (C.P.D.); Departments of Psychiatry, Radiology, and Neuroscience (M.S.G.) and Public Health Sciences (Y.Y.P., W.Z.), Medical University of South Carolina, Charleston; Ralph H Johnson VA Medical Center, Charleston, SC (M.S.G.); University of Texas Southwestern Medical Center, Austin (S.W.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Departments of Neurology, Public Health Sciences, Human Genetics, and Neurosurgery, Miller School of Medicine, University of Miami, FL (R.L.S.); Department of Neurology, University of Cincinnati, OH (P.K., J.P.B.); Department of Neurology, University of California, Irvine (S.C.C.); and Department of Rehabilitation Medicine, Emory University School of Medicine and Center for Visual and Cognitive Neurorehabilitation, Atlanta VA Medical Center, GA (S.L.W.). , Jeffrey L. SaverJeffrey L. Saver From the Neurovascular Imaging Research Core (D.S.L.) and Department of Neurology, Comprehensive Stroke Center, Geffen School of Medicine (D.S.L., J.L.S.), University of California, Los Angeles; Departments of Neurology (G.W.A.) and Radiology (M.W.), Stanford University, Palo Alto, CA; Laboratory of Neuro Imaging, Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles (K.C., A.W.T.); Departments of Neurology and Neurological Surgery, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO (C.P.D.); Departments of Psychiatry, Radiology, and Neuroscience (M.S.G.) and Public Health Sciences (Y.Y.P., W.Z.), Medical University of South Carolina, Charleston; Ralph H Johnson VA Medical Center, Charleston, SC (M.S.G.); University of Texas Southwestern Medical Center, Austin (S.W.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Departments of Neurology, Public Health Sciences, Human Genetics, and Neurosurgery, Miller School of Medicine, University of Miami, FL (R.L.S.); Department of Neurology, University of Cincinnati, OH (P.K., J.P.B.); Department of Neurology, University of California, Irvine (S.C.C.); and Department of Rehabilitation Medicine, Emory University School of Medicine and Center for Visual and Cognitive Neurorehabilitation, Atlanta VA Medical Center, GA (S.L.W.). , Steven C. CramerSteven C. Cramer From the Neurovascular Imaging Research Core (D.S.L.) and Department of Neurology, Comprehensive Stroke Center, Geffen School of Medicine (D.S.L., J.L.S.), University of California, Los Angeles; Departments of Neurology (G.W.A.) and Radiology (M.W.), Stanford University, Palo Alto, CA; Laboratory of Neuro Imaging, Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles (K.C., A.W.T.); Departments of Neurology and Neurological Surgery, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO (C.P.D.); Departments of Psychiatry, Radiology, and Neuroscience (M.S.G.) and Public Health Sciences (Y.Y.P., W.Z.), Medical University of South Carolina, Charleston; Ralph H Johnson VA Medical Center, Charleston, SC (M.S.G.); University of Texas Southwestern Medical Center, Austin (S.W.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Departments of Neurology, Public Health Sciences, Human Genetics, and Neurosurgery, Miller School of Medicine, University of Miami, FL (R.L.S.); Department of Neurology, University of Cincinnati, OH (P.K., J.P.B.); Department of Neurology, University of California, Irvine (S.C.C.); and Department of Rehabilitation Medicine, Emory University School of Medicine and Center for Visual and Cognitive Neurorehabilitation, Atlanta VA Medical Center, GA (S.L.W.). , Steven L. WolfSteven L. Wolf From the Neurovascular Imaging Research Core (D.S.L.) and Department of Neurology, Comprehensive Stroke Center, Geffen School of Medicine (D.S.L., J.L.S.), University of California, Los Angeles; Departments of Neurology (G.W.A.) and Radiology (M.W.), Stanford University, Palo Alto, CA; Laboratory of Neuro Imaging, Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles (K.C., A.W.T.); Departments of Neurology and Neurological Surgery, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO (C.P.D.); Departments of Psychiatry, Radiology, and Neuroscience (M.S.G.) and Public Health Sciences (Y.Y.P., W.Z.), Medical University of South Carolina, Charleston; Ralph H Johnson VA Medical Center, Charleston, SC (M.S.G.); University of Texas Southwestern Medical Center, Austin (S.W.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Departments of Neurology, Public Health Sciences, Human Genetics, and Neurosurgery, Miller School of Medicine, University of Miami, FL (R.L.S.); Department of Neurology, University of Cincinnati, OH (P.K., J.P.B.); Department of Neurology, University of California, Irvine (S.C.C.); and Department of Rehabilitation Medicine, Emory University School of Medicine and Center for Visual and Cognitive Neurorehabilitation, Atlanta VA Medical Center, GA (S.L.W.). , Joseph P. BroderickJoseph P. Broderick From the Neurovascular Imaging Research Core (D.S.L.) and Department of Neurology, Comprehensive Stroke Center, Geffen School of Medicine (D.S.L., J.L.S.), University of California, Los Angeles; Departments of Neurology (G.W.A.) and Radiology (M.W.), Stanford University, Palo Alto, CA; Laboratory of Neuro Imaging, Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles (K.C., A.W.T.); Departments of Neurology and Neurological Surgery, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO (C.P.D.); Departments of Psychiatry, Radiology, and Neuroscience (M.S.G.) and Public Health Sciences (Y.Y.P., W.Z.), Medical University of South Carolina, Charleston; Ralph H Johnson VA Medical Center, Charleston, SC (M.S.G.); University of Texas Southwestern Medical Center, Austin (S.W.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Departments of Neurology, Public Health Sciences, Human Genetics, and Neurosurgery, Miller School of Medicine, University of Miami, FL (R.L.S.); Department of Neurology, University of Cincinnati, OH (P.K., J.P.B.); Department of Neurology, University of California, Irvine (S.C.C.); and Department of Rehabilitation Medicine, Emory University School of Medicine and Center for Visual and Cognitive Neurorehabilitation, Atlanta VA Medical Center, GA (S.L.W.). and Max WintermarkMax Wintermark From the Neurovascular Imaging Research Core (D.S.L.) and Department of Neurology, Comprehensive Stroke Center, Geffen School of Medicine (D.S.L., J.L.S.), University of California, Los Angeles; Departments of Neurology (G.W.A.) and Radiology (M.W.), Stanford University, Palo Alto, CA; Laboratory of Neuro Imaging, Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles (K.C., A.W.T.); Departments of Neurology and Neurological Surgery, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO (C.P.D.); Departments of Psychiatry, Radiology, and Neuroscience (M.S.G.) and Public Health Sciences (Y.Y.P., W.Z.), Medical University of South Carolina, Charleston; Ralph H Johnson VA Medical Center, Charleston, SC (M.S.G.); University of Texas Southwestern Medical Center, Austin (S.W.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Departments of Neurology, Public Health Sciences, Human Genetics, and Neurosurgery, Miller School of Medicine, University of Miami, FL (R.L.S.); Department of Neurology, University of Cincinnati, OH (P.K., J.P.B.); Department of Neurology, University of California, Irvine (S.C.C.); and Department of Rehabilitation Medicine, Emory University School of Medicine and Center for Visual and Cognitive Neurorehabilitation, Atlanta VA Medical Center, GA (S.L.W.). Originally published4 Jun 2015https://doi.org/10.1161/STROKEAHA.115.009479Stroke. 2015;46:2000–2006Other version(s) of this articleYou are viewing the most recent version of this article. Previous versions: January 1, 2015: Previous Version 1 Imaging of stroke and neurovascular disorders has profoundly enhanced clinical practice and related research during the past 40 years since the introduction of computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography enabled mapping of the brain. Various imaging techniques have been developed to study stroke pathophysiology and inform medical decision-making in prevention, prehospital care, acute monitoring of revascularization, during the subacute ICU course, and recovery settings. The technology to acquire such imaging with sophisticated scanners, software for rapid postprocessing, analysis, computer vision methods, and telemedicine platforms to instantly beam such information around the world now warrant reconsideration of the potential of stroke imaging in the era of big data.These dramatic changes in neuroimaging and the vast potential to catapult stroke care depend on large-scale, multi-institutional research initiatives to establish their role. These initiatives would require that the current infrastructure and philosophy of translational research must be modernized to incorporate such advances. In this position paper, we describe the historical context, conceptual framework, current issues, logical analyses for strategic planning, and the proposed aims of future stroke imaging initiatives to advance data science with the recently established National Institutes of Health (NIH) StrokeNet.1 The StrokeNet consists of 25 regional stroke center hubs, each associated with a group of spoke hospitals that are capable of conducting stroke research. The network will be responsible for conducting future multicenter NIH stroke trials and represents an ideal setting to capture large volumes of invaluable neuroimaging data.Our perspective contrasts with the limited translational research use of imaging in most previous stroke trials, recognizing a unique opportunity to maximize data science and leverage this landmark NIH investment to transform stroke trials of prevention, acute treatment, and recovery. The tools already exist for widespread acquisition and transmission of image data, systematic real-time extraction of discrete imaging variables, enabling creation of an enduring and valuable resource for future research, education, and clinical uses. We outline 3 innovative specific aims that focus on establishing the dedicated infrastructure, archival process, and centralized core laboratory function to provide a foundation for stroke imaging studies that fully realize the potential of big data.Historical ContextDuring the past decade, we have witnessed a convergence of 3 simultaneous evolutions in biomedical research related to stroke and neurovascular disorders. Stroke imaging, large-scale development of stroke research networks, and the modernization of medicine and neuroscience with large data sets are now capable of intersecting with related, yet potentially divergent, trajectories.Stroke and Neurovascular ImagingThe approval of intravenous tissue-type plasminogen activator for thrombolysis prompted the use of noncontrast CT to primarily rule out hemorrhage before treatment because early ischemic changes were generally considered inconsequential. The development of noninvasive angiography, perfusion imaging with CT and MRI techniques, and parenchymal MRI sequences such as diffusion-weighted imaging subsequently provided clinicians with enhanced ability to rapidly diagnose and treat acute stroke.2 The use of these multimodal CT and MRI protocols rapidly increased, augmenting our knowledge within a few short years on stroke pathophysiology. In the early 2000s, stroke trials started to embed such imaging as screening tools and secondary outcome measures for novel drugs and then devices. Even while stroke trials struggled to establish new treatments, advanced image analyses often yielded new insight.3 For example, the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution (DEFUSE) trialists demonstrated that specific patterns of evolving ischemic injury could be used to predict subsequent clinical outcomes after revascularization.4,5Several trials using imaging as a screening/selection criterion provided mixed, positive, and negative results. Some concluded that imaging has failed us and that the imaging-based trials did not demonstrate the need for such costly diagnostic tests. The lack of central coordinated and standardized collection of the image data from these different trials limited pooled analysis of these dat
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