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Natural Killer Cell Memory

2015; Cell Press; Volume: 43; Issue: 4 Linguagem: Inglês

10.1016/j.immuni.2015.09.013

1097-4180

Timothy E. O’Sullivan, Joseph C. Sun, Lewis L. Lanier,

Autoimmune and Inflammatory Disorders Research

Natural killer (NK) cells have historically been considered short-lived cytolytic cells that can rapidly respond against pathogens and tumors in an antigen-independent manner and then undergo cell death. Recently, however, NK cells have been shown to possess traits of adaptive immunity and can acquire immunological memory in a manner similar to that of T and B cells. In this review, we discuss evidence of NK cell memory and the mechanisms involved in the generation and survival of these innate lymphocytes.