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Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management

2015; American Society for Microbiology; Volume: 28; Issue: 3 Linguagem: Inglês

10.1128/cmr.00134-14

1098-6618

Steven Y. C. Tong, Joshua S. Davis, Emily M. Eichenberger, Thomas L Holland, Vance G. Fowler,

Streptococcal Infections and Treatments

SUMMARY Staphylococcus aureus is a major human pathogen that causes a wide range of clinical infections. It is a leading cause of bacteremia and infective endocarditis as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device-related infections. This review comprehensively covers the epidemiology, pathophysiology, clinical manifestations, and management of each of these clinical entities. The past 2 decades have witnessed two clear shifts in the epidemiology of S. aureus infections: first, a growing number of health care-associated infections, particularly seen in infective endocarditis and prosthetic device infections, and second, an epidemic of community-associated skin and soft tissue infections driven by strains with certain virulence factors and resistance to β-lactam antibiotics. In reviewing the literature to support management strategies for these clinical manifestations, we also highlight the paucity of high-quality evidence for many key clinical questions.