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Endogenously labeled low density lipoprotein triglyceride and apoprotein B kinetics.

1978; Elsevier BV; Volume: 19; Issue: 8 Linguagem: Inglês

10.1016/s0022-2275(20)40681-9

1539-7262

Claude L. Malmendier, M. Berman,

Lipoproteins and Cardiovascular Health

The kinetics of endogenously labeled low density lipoprotein (LDL) triglycerides (TG) and apoprotein B (apoB) have been studied in four normal and in four hyperlipemic subjects using double tracers.Analysis of the data suggests that most LDL triglycerides turn over about 10 times faster than apoB (0.003/min vs. 0.0003imin) and that about 10% of the LDL particles contain most of the T G found with LDL.It is not possible to determine from the analysis whether each new LDL particle arrives with the excess T G or whether only a subpopulation of particles contains most of the TG.The kinetic analysis further suggests that triglyceride-rich LDL particles do not exchange with an extraplasma compartment as most LDL particles do, and thus, they behave more like very low density lipoprotein particles.A compartmental model accounting for both the LDL-TC and LDL-apoB kinetics is proposed.Supplementary key words fractional turnoter rate .